Evidence map›Paper›PMID 17868854›Full record

ReviewImmunology and allergy clinics of North America2007

Mechanisms of eosinophilia in the pathogenesis of hypereosinophilic disorders.

Steven J Ackerman, Bruce S Bochner

Open access · greenAbstract readReview
In one paragraph

Review in Immunology and allergy clinics of North America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 119 citations in OpenAlex.

  1. Article
  2. Review
  3. Burden of hypereosinophilic syndromes in the United States: Patients' perspective.The journal of allergy and clinical immunology. Global · 2025
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. HES and EGPA: Two Sides of the Same Coin.Mayo Clinic proceedings · 2023
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Steven J AckermanDepartment of Biochemistry and Molecular Genetics (M/C 669), Molecular Biology Research Building, Rm. 2074, 900 S. Ashland Avenue, The University of Illinois at Chicago College of Medicine, Chicago, IL 60607, USA.
Bruce S Bochner
Johns Hopkins University · USUniversity of Illinois Chicago · US

Funding

Targeting Siglec-8/Siglec-F Reduce Allergic Responses In Vitro and In VivoR01AI072265 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BOCHNER, BRUCE S · 2007 to 2017
$3.9M
INTEGRINS AND CHEMOKINES IN ALLERGIC CELL RECRUITMENTR01AI041472 · NIAID · JOHNS HOPKINS UNIVERSITY · PI BOCHNER, BRUCE S · 1998 to 2007
$2.5M
CYTOKINE REGULATION OF HUMAN EOSINOPHIL GENESR01AI033043 · NIAID · UNIVERSITY OF ILLINOIS AT CHICAGO · PI ACKERMAN, STEVEN JULES · 1992 to 2006
$2.2M
INTEGRINS AND CHEMOKINES IN ALLERGIC CELL RECRUITMENTR21AI041472 · NIAID · JOHNS HOPKINS UNIVERSITY · PI BOCHNER, BRUCE S · 1997 to 2003
$92k
NIAID NIH HHS AI033043NIAID NIH HHS AI041472NIAID NIH HHS R01 AI033043NIAID NIH HHS R01 AI041472NIAID NIH HHS R01 AI072265NIAID NIH HHS R21 AI041472
6 · The paper itself

Abstract

The increased numbers of activated eosinophils in the blood and tissues that typically accompany hypereosinophilic disorders result from a variety of mechanisms. Exciting advances in translating discoveries achieved from mouse models and molecular strategies to the clinic have led to a flurry of new therapeutics specifically designed to target eosinophil-associated diseases. So far, this form of hypothesis testing in humans in vivo through pharmacology generally has supported the paradigms generated in vitro and in animal models, raising hopes that a spectrum of novel therapies soon may become available to help those who have eosinophil-associated diseases.

Indexed as

AnimalsCell DegranulationChemotactic Factors, EosinophilCytokinesEosinophil Granule ProteinsEosinophilsHumansHypereosinophilic SyndromeInflammation MediatorsLeukopoiesisChemotactic Factors, EosinophilCytokinesEosinophil Granule ProteinsInflammation Mediators

Identifiers

PMID17868854
PMCPMC2064859
OpenAlexW2060771250

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.