ArticleJournal of neurochemistry2007
Neurexin Ibeta and neuroligin are localized on opposite membranes in mature central synapses.
Article in Journal of neurochemistry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 43 citations in OpenAlex.
- Latrophilin-1-Mediated GCells · 2026Article
- Perturbed synaptic adhesion molecules signaling in neurodevelopmental disorders: The impact of metal neurotoxicity.Ibrain · 2025Review
- Alpha-neurexins in health and disease.Frontiers in molecular neuroscience · 2025Review
- ADGRL1 haploinsufficiency causes a variable spectrum of neurodevelopmental disorders in humans and alters synaptic activity and behavior in a mouse model.American journal of human genetics · 2022Article
- Catching Latrophilin With Lasso: A Universal Mechanism for Axonal Attraction and Synapse Formation.Frontiers in neuroscience · 2019Review
- Increased CaMolecular autism · 2019Article
- Neuroligin 4 regulates synaptic growth via the bone morphogenetic protein (BMP) signaling pathway at theThe Journal of biological chemistry · 2017Article
- Synapse biology in the 'circuit-age'-paths toward molecular connectomics.Current opinion in neurobiology · 2017Review
- The Mechanism of Regulated Release of Lasso/Teneurin-2.Frontiers in molecular neuroscience · 2016Article
- Article
- Differential centrifugation-based biochemical fractionation of the Drosophila adult CNS.Nature protocols · 2014Article
- Intercellular protein-protein interactions at synapses.Protein & cell · 2014Review
- Article
- Neurexins.Genome biology · 2013Review
- Drosophila neuroligin 2 is required presynaptically and postsynaptically for proper synaptic differentiation and synaptic transmission.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Neurexin-1α contributes to insulin-containing secretory granule docking.The Journal of biological chemistry · 2012Article
- Neurexins and neuroligins: recent insights from invertebrates.Molecular neurobiology · 2011Review
- Latrophilin 1 and its endogenous ligand Lasso/teneurin-2 form a high-affinity transsynaptic receptor pair with signaling capabilities.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Neurexins, neuroligins and LRRTMs: synaptic adhesion getting fishy.Journal of neurochemistry · 2011Review
- Differential expression of presynaptic genes in a rat model of postnatal hypoxia: relevance to schizophrenia.European archives of psychiatry and clinical neuroscience · 2010Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Synaptogenesis requires formation of trans-synaptic complexes between neuronal cell-adhesion receptors. Heterophilic receptor pairs, such as neurexin Ibeta and neuroligin, can mediate distinct intracellular signals and form different cytoplasmic scaffolds in the pre- and post-synaptic neuron, and may be particularly important for synaptogenesis. However, the functions of neurexin and neuroligin depend on their distribution in the synapse. Neuroligin has been experimentally assigned to the post-synaptic membrane, while the localization of neurexin remains unclear. To study the subcellular distribution of neurexin Ibeta and neuroligin in mature cerebrocortical synapses, we have developed a novel method for the physical separation of junctional membranes and their direct analysis by western blotting. Using urea and dithiothreitol, we disrupted trans-synaptic protein links, without dissolving the lipid phase, and fractionated the pre- and post-synaptic membranes. The purity of these fractions was validated by electron microscopy and western blotting using multiple synaptic markers. A quantitative analysis has confirmed that neuroligin is localized strictly in the post-synaptic membrane. We have also demonstrated that neurexin Ibeta is largely (96%) pre-synaptic. Thus, neurexin Ibeta and neuroligin normally form trans-synaptic complexes and can transduce bidirectional signals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.