ArticleNucleic acids research2007
Dynamic interactions within sub-complexes of the H/ACA pseudouridylation guide RNP.
Article in Nucleic acids research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
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- The Kink Turn, a Key Architectural Element in RNA Structure.Journal of molecular biology · 2016Review
- Revisiting the structure/function relationships of H/ACA(-like) RNAs: a unified model for Euryarchaea and Crenarchaea.Nucleic acids research · 2015Article
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- The L7Ae protein binds to two kink-turns in the Pyrococcus furiosus RNase P RNA.Nucleic acids research · 2014Article
- The K-turn motif in riboswitches and other RNA species.Biochimica et biophysica acta · 2014Review
- The molecular recognition of kink-turn structure by the L7Ae class of proteins.RNA (New York, N.Y.) · 2013Article
- Alternative processing as evolutionary mechanism for the origin of novel nonprotein coding RNAs.Genome biology and evolution · 2013Article
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- Structure and folding of a rare, natural kink turn in RNA with an A*A pair at the 2b*2n position.RNA (New York, N.Y.) · 2012Article
- Binding and cleavage of CRISPR RNA by Cas6.RNA (New York, N.Y.) · 2010Article
- A structural database for k-turn motifs in RNA.RNA (New York, N.Y.) · 2010Article
- Ion-induced folding of a kink turn that departs from the conventional sequence.Nucleic acids research · 2009Article
- Cas6 is an endoribonuclease that generates guide RNAs for invader defense in prokaryotes.Genes & development · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
H/ACA RNP complexes change uridines to pseudouridines in target non-coding RNAs in eukaryotes and archaea. H/ACA RNPs are comprised of a guide RNA and four essential proteins: Cbf5 (pseudouridine synthase), L7Ae, Gar1 and Nop10 in archaea. The guide RNA captures the target RNA via two antisense elements brought together to form a contiguous binding site within the pseudouridylation pocket (internal loop) of the guide RNA. Cbf5 and L7Ae interact independently with the guide RNA, and here we have examined the impacts of these proteins on the RNA in nucleotide protection assays. The results indicate that the interactions observed in a fully assembled H/ACA RNP are established in the sub-complexes, but also reveal a unique Cbf5-guide RNA interaction that is displaced by L7Ae. In addition, the results indicate that L7Ae binding at the kink (k)-turn of the guide RNA induces the formation of the upper stem, and thus also the pseudouridylation pocket. Our findings indicate that L7Ae is essential for formation of the substrate RNA binding site in the archaeal H/ACA RNP, and suggest that k-turn-binding proteins may remodel partner RNAs with important effects distant from the protein-binding site.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.