ArticleNucleic acids research2007
Deletion of the nuclear exosome component RRP6 leads to continued accumulation of the histone mRNA HTB1 in S-phase of the cell cycle in Saccharomyces cerevisiae.
Article in Nucleic acids research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Transcription coordinates histone amounts and genome content.Nature communications · 2021Article
- SAGA DUBm-mediated surveillance regulates prompt export of stress-inducible transcripts for proteostasis.Nature communications · 2019Article
- Regulation of DNA replication-coupled histone gene expression.Oncotarget · 2017Review
- Identification of karyopherins involved in the nuclear import of RNA exosome subunit Rrp6 inThe Journal of biological chemistry · 2017Article
- Loss of the RNA helicase SKIV2L2 impairs mitotic progression and replication-dependent histone mRNA turnover in murine cell lines.RNA (New York, N.Y.) · 2017Article
- Comparative Analysis of the Antimicrobial Activities of Plant Defensin-Like and Ultrashort Peptides against Food-Spoiling Bacteria.Applied and environmental microbiology · 2016Article
- The regulation and functions of the nuclear RNA exosome complex.Nature reviews. Molecular cell biology · 2016Review
- Eri1: a conserved enzyme at the crossroads of multiple RNA-processing pathways.Trends in genetics : TIG · 2014Review
- mRNA stability in the nucleus.Journal of Zhejiang University. Science. B · 2014Review
- Regulation of histone gene transcription in yeast.Cellular and molecular life sciences : CMLS · 2014Review
- The PolyA tail length of yeast histone mRNAs varies during the cell cycle and is influenced by Sen1p and Rrp6p.Nucleic acids research · 2012Article
- Yeast nuclear RNA processing.World journal of biological chemistry · 2012Article
- Regulation of conditional gene expression by coupled transcription repression and RNA degradation.Nucleic acids research · 2012Article
- Activities of human RRP6 and structure of the human RRP6 catalytic domain.RNA (New York, N.Y.) · 2011Article
- The exozyme model: a continuum of functionally distinct complexes.RNA (New York, N.Y.) · 2011Review
- Core exosome-independent roles for Rrp6 in cell cycle progression.Molecular biology of the cell · 2009Article
- Quality control of mRNP in the nucleus.Chromosoma · 2008Review
- New ways to meet your (3') end oligouridylation as a step on the path to destruction.Genes & development · 2008Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The nuclear exosome, a macromolecular complex of 3' to 5' exonucleases, is required for the post-transcriptional processing of a variety of RNAs including rRNAs and snoRNAs. Additionally, this complex forms part of a nuclear surveillance network where it acts to degrade any aberrantly processed mRNAs in the nucleus. The exosome complex has been implicated in the biogenesis pathway of general messenger RNAs through its interaction with the 3'-end processing machinery. During the cell cycle, yeast histone mRNAs accumulate in the S-phase and are rapidly degraded as cells enter the G2-phase. To determine if the exosome contributes to the cyclic turnover of yeast histone mRNAs, we examined the pattern of accumulation of 'HTB1' mRNA during the cell cycle in a deletion strain of 'RRP6', a component of the nuclear exosome. Our results show that cells lacking Rrp6p continue to accumulate HTB1 mRNA as the cell cycle proceeds. This continued accumulation appears to result from a delay in exit from S-phase in rrp6 cells. The accumulation of HTB1 mRNA in rrp6 cells is influenced by the interaction of the nuclear exosome with the 3'-end processing machinery although there is no evidence for differential regulation of histone mRNA 3'-end processing during the yeast cell cycle.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.