ArticleFEMS microbiology letters2007
Existence and characterization of allelic variants of Sao, a newly identified surface protein from Streptococcus suis.
Article in FEMS microbiology letters, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- Preparation and Study of Bacterins.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Comparative Virulence and Genomic Analysis ofFrontiers in microbiology · 2020Article
- Identification of a Novel Linear B Cell Epitope on the Sao Protein ofFrontiers in immunology · 2020Article
- A critical review speculating on the protective efficacies of autogenousPorcine health management · 2020Review
- Streptococcus suis in invasive human infections in Poland: clonality and determinants of virulence and antimicrobial resistance.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2016Article
- Loss of 89K Pathogenicity Island in Epidemic Streptococcus suis, China.Emerging infectious diseases · 2016Article
- Isolation and characterization of a native avirulent strain of Streptococcus suis serotype 2: a perspective for vaccine development.Scientific reports · 2015Article
- Gluconate 5-dehydrogenase (Ga5DH) participates in Streptococcus suis cell division.Protein & cell · 2014Article
- Streptococcus suis infection: an emerging/reemerging challenge of bacterial infectious diseases?Virulence · 2014Review
- The β-galactosidase (BgaC) of the zoonotic pathogen Streptococcus suis is a surface protein without the involvement of bacterial virulence.Scientific reports · 2014Article
- Attenuation of Streptococcus suis virulence by the alteration of bacterial surface architecture.Scientific reports · 2012Article
- Inactivation of dipeptidyl peptidase IV attenuates the virulence of Streptococcus suis serotype 2 that causes streptococcal toxic shock syndrome.Current microbiology · 2009Article
- Fusion expression and immunogenicity of EHEC EspA-Stx2Al protein: implications for the vaccine development.Journal of microbiology (Seoul, Korea) · 2009Article
- Functional definition and global regulation of Zur, a zinc uptake regulator in a Streptococcus suis serotype 2 strain causing streptococcal toxic shock syndrome.Journal of bacteriology · 2008Article
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Corrections and comments
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Authors and funding
13 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Surface antigen one (Sao) is a newly identified protein from the major zoonotic pathogen, Streptococcus suis. In search of functional proteins related to the pathogenesis of Chinese S. suis 2 (SS2), unexpectedly, a variant of Sao protein was obtained. To test its prevalence in S. suis, PCR assay was adopted to address the coding genes systematically. It was found that there are three allelic variants of sao gene, namely sao-S, sao-M, and sao-L based on the different lengths of the genes (approximately 1.5, approximately 1.7, and approximately 2.0 kb, respectively). These differences were determined to be caused by heterogeneity within the number of C-terminal repeat sequences (R), which had been seen as a pathogenicity-related domain in the plant pathogen, Xanthomonas oryzae. Two variants (sao-M and sao-L) were only found in SS2. All three variant proteins were prepared in vitro and their biochemical and biophysical properties were characterized. A soluble form of Sao-M protein was then used as a capture antigen to develop an enzyme-linked immunosorbent assay method to detect antibodies against SS2 in convalescent pig sera. Taken together, the results exhibit the properties of Sao proteins and provide an efficient Sao-M-based method for monitoring SS2 infection.
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