ReviewWorld journal of gastroenterology2007
Implication of altered proteasome function in alcoholic liver injury.
Review in World journal of gastroenterology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 42 citations in OpenAlex.
- Embryonic alcohol exposure disrupts the ubiquitin-proteasome system.JCI insight · 2022Article
- Review
- Alcohol-Induced Lysosomal Damage and Suppression of Lysosome Biogenesis Contribute to Hepatotoxicity in HIV-Exposed Liver Cells.Biomolecules · 2021Article
- A Novel Dual Drug Approach That Combines Ivermectin and Dihydromyricetin (DHM) to Reduce Alcohol Drinking and Preference in Mice.Molecules (Basel, Switzerland) · 2021Article
- Dihydromyricetin Protects the Liver via Changes in Lipid Metabolism and Enhanced Ethanol Metabolism.Alcoholism, clinical and experimental research · 2020Article
- Phosphodiesterase 4 Inhibition as a Therapeutic Target for Alcoholic Liver Disease: From Bedside to Bench.Hepatology (Baltimore, Md.) · 2019Article
- Pathogenesis of alcoholic liver disease: role of oxidative metabolism.World journal of gastroenterology · 2014Review
- Autophagy in alcohol-induced multiorgan injury: mechanisms and potential therapeutic targets.BioMed research international · 2014Review
- Antioxidant activity and hepatoprotective potential of Hammada scoparia against ethanol-induced liver injury in rats.Journal of physiology and biochemistry · 2013Article
- Convergent mechanisms for dysregulation of mitochondrial quality control in metabolic disease: implications for mitochondrial therapeutics.Biochemical Society transactions · 2013Review
- Impact of altered methylation in cytokine signaling and proteasome function in alcohol and viral-mediated diseases.Alcoholism, clinical and experimental research · 2013Review
- Ethanol and hepatitis C virus suppress peptide-MHC class I presentation in hepatocytes by altering proteasome function.Alcoholism, clinical and experimental research · 2012Article
- Alcohol and hepatitis C virus--interactions in immune dysfunctions and liver damage.Alcoholism, clinical and experimental research · 2010Review
- Alcohol-induced alterations of the hepatocyte cytoskeleton.World journal of gastroenterology · 2010Review
- Effects of ethanol on the proteasome interacting proteins.World journal of gastroenterology · 2010Review
- Impaired methylation as a novel mechanism for proteasome suppression in liver cells.Biochemical and biophysical research communications · 2010Article
- Focus on the liver: alcohol use, highly active antiretroviral therapy, and liver disease in HIV-infected patients.Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism · 2010Review
- Chronic ethanol feeding affects proteasome-interacting proteins.Proteomics · 2009Article
- Nuclear effects of ethanol-induced proteasome inhibition in liver cells.World journal of gastroenterology · 2009Article
- Acute alcohol intoxication increases atrogin-1 and MuRF1 mRNA without increasing proteolysis in skeletal muscle.American journal of physiology. Regulatory, integrative and comparative physiology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The proteasome is a major protein-degrading enzyme, which catalyzes degradation of oxidized and aged proteins, signal transduction factors and cleaves peptides for antigen presentation. Proteasome exists in the equilibrium of 26S and 20S particles. Proteasome function is altered by ethanol metabolism, depending on oxidative stress levels: low oxidative stress induces proteasome activity, while high oxidative stress reduces it. The proposed mechanisms for modulation of proteasome activity are related to oxidative modification of proteasomal proteins with primary and secondary products derived from ethanol oxidation. Decreased proteolysis by the proteasome results in the accumulation of insoluble protein aggregates, which cannot be degraded by proteasome and which further inhibit proteasome function. Mallory bodies, a common signature of alcoholic liver diseases, are formed by liver cells, when proteasome is unable to remove cytokeratins. Proteasome inhibition by ethanol also promotes the accumulation of pro-apoptotic factors in mitochondria of ethanol-metabolizing liver cells that are normally degraded by proteasome. In addition, decreased proteasome function also induces accumulation of the negative regulators of cytokine signaling (I-kappaB and SOCS), thereby blocking cytokine signal transduction. Finally, ethanol-elicited blockade of interferon type 1 and 2 signaling and decreased proteasome function impairs generation of peptides for MHC class I-restricted antigen presentation.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.