ArticleCanadian journal of gastroenterology = Journal canadien de gastroenterologie2007
Granuloma-positive Crohn's disease.
Article in Canadian journal of gastroenterology = Journal canadien de gastroenterologie, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Systematic Review: Evaluating the Prognostic Value of Granulomas in Crohn's Disease.Digestive diseases and sciences · 2026Pooled it
- Crohn's lymphoid aggregates with endothelial clusters colocalise with submucosal fibrosis in fibrostenosing Crohn's disease.The Journal of pathology · 2026Article
- Diagnostic Challenges in Enteropathies: A Histopathological Review.Diagnostics (Basel, Switzerland) · 2025Review
- Asia Pacific association of gastroenterology consensus statements on histopathological evaluation of inflammatory bowel diseases.Therapeutic advances in gastroenterology · 2025Article
- Macrophage and neutrophil heterogeneity at single-cell spatial resolution in human inflammatory bowel disease.Nature communications · 2023Article
- Frequent Occurrence of Perianal Disease and Granuloma Formation in Patients with Crohn's Disease and Coexistent Orofacial Granulomatosis.Digestive diseases and sciences · 2023Article
- Histopathological assessment of the microscopic activity in inflammatory bowel diseases: What are we looking for?World journal of gastroenterology · 2022Review
- The gastric microbiota in patients with Crohn's disease; a preliminary study.Scientific reports · 2021Article
- Crohn's disease of esophagus, stomach and duodenum.World journal of gastrointestinal pharmacology and therapeutics · 2019Review
- An Expandable Mechanopharmaceutical Device (2): Drug Induced Granulomas Maximize the Cargo Sequestering Capacity of Macrophages in the Liver.Pharmaceutical research · 2018Article
- Selective M1 macrophage polarization in granuloma-positive and granuloma-negative Crohn's disease, in comparison to intestinal tuberculosis.Intestinal research · 2018Article
- Segmental colitis associated with diverticulosis: is it the coexistence of colonic diverticulosis and inflammatory bowel disease?Annals of gastroenterology · 2017Review
- Histopathological findings of extra-ileal manifestations at initial diagnosis of Crohn's disease-related ileitis.Virchows Archiv : an international journal of pathology · 2016Article
- CCR9 antagonism: potential in the treatment of Inflammatory Bowel Disease.Clinical and experimental gastroenterology · 2015Review
- Natural history and long-term clinical course of Crohn's disease.World journal of gastroenterology · 2014Review
- Eosinophil associated genes in the inflammatory bowel disease 4 region: correlation to inflammatory bowel disease revealed.World journal of gastroenterology · 2012Article
- Predictors of aggressive inflammatory bowel disease.Gastroenterology & hepatology · 2011Article
- Infliximab therapy impacts the peripheral immune system of immunomodulator and corticosteroid naïve patients with Crohn's disease.Gut and liver · 2011Article
- Sulfasalazine and mesalamine modulate beryllium-specific lymphocyte proliferation and inflammatory cytokine production.American journal of respiratory cell and molecular biology · 2010Article
- Relevance of segmental colitis with diverticulosis (SCAD) to other forms of inflammatory bowel disease.Canadian journal of gastroenterology = Journal canadien de gastroenterologie · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe epithelioid granuloma is a characteristic histological feature of Crohn's disease. In some pathological classification schemes, the criteria for a definite, probable or possible diagnosis have been listed, with the epithelioid granuloma indicating definite Crohn's disease.
methodsIn the present evaluation, 247 prospectively evaluated Crohn's disease patients (24.3%), from a consecutively accumulated population database of 1015 patients, were found to have an epithelioid granuloma. The recently devised Montreal classification for Crohn's disease was then applied to this granuloma-positive cohort of Crohn's disease patients to define age at diagnosis for men and women, disease site and disease behaviour.
resultsThe investigation showed that patients with Crohn's disease and granulomas were most often diagnosed early in the course of their disease, particularly women. Their disease was often extensive, with ileocolonic and upper gastrointestinal tract involvement. Finally, disease behaviour was most often complex, especially with penetrating disease complications.
conclusionUsing homogeneous (ie, 'reagent-grade') patient cohorts defined by a recently devised classification method for Crohn's disease, the study demonstrated that an epithelioid granuloma may represent a histopathological marker for an early biological event in the etiopathogenesis of Crohn's disease, and this may have predictive significance with respect to the location and clinical behaviour of Crohn's disease.
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