ArticleScandinavian journal of infectious diseases2008
The platelet activating factor receptor is not required for exacerbation of bacterial pneumonia following influenza.
Article in Scandinavian journal of infectious diseases, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- Respiratory tract barrier dysfunction in viral-bacterial co-infection cases.The Japanese dental science review · 2024Review
- Increased lethality of respiratory infection byFASEB bioAdvances · 2023Article
- Article
- Effect of Influenza Vaccine on Prevention of Acute Attack of Chronic Airway Disease in Elderly Population.Vaccines · 2022Article
- The Effectiveness of Influenza Vaccination on Chronic Obstructive Pulmonary Disease with Different Severities of Airflow Obstruction.Biomedicines · 2021Article
- GP96 Drives Exacerbation of Secondary Bacterial Pneumonia following Influenza A Virus Infection.mBio · 2021Article
- Molecular pathogenesis of secondary bacterial infection associated to viral infections including SARS-CoV-2.Journal of infection and public health · 2020Review
- Why Are Children With Bronchiolitis At Risk Of Urinary Tract Infections?Risk management and healthcare policy · 2019Article
- Secondary Bacterial Infections Associated with Influenza Pandemics.Frontiers in microbiology · 2017Review
- Mathematical modeling of postcoinfection with influenza A virus andInternational journal of chronic obstructive pulmonary disease · 2017Article
- Virus-induced secondary bacterial infection: a concise review.Therapeutics and clinical risk management · 2015Review
- Time and dose-dependent risk of pneumococcal pneumonia following influenza: a model for within-host interaction between influenza and Streptococcus pneumoniae.Journal of the Royal Society, Interface · 2013Article
- Immune dysfunction and bacterial coinfections following influenza.Journal of immunology (Baltimore, Md. : 1950) · 2013Review
- Type I interferon protects against pneumococcal invasive disease by inhibiting bacterial transmigration across the lung.PLoS pathogens · 2013Article
- Clarithromycin suppresses human respiratory syncytial virus infection-induced Streptococcus pneumoniae adhesion and cytokine production in a pulmonary epithelial cell line.Mediators of inflammation · 2012Article
- Pathogenesis and pathophysiology of pneumococcal meningitis.Clinical microbiology reviews · 2011Review
- Infection with human coronavirus NL63 enhances streptococcal adherence to epithelial cells.The Journal of general virology · 2011Article
- Preventing and treating secondary bacterial infections with antiviral agents.Antiviral therapy · 2011Review
- The airway epithelium: soldier in the fight against respiratory viruses.Clinical microbiology reviews · 2011Review
- Platelet-activating factor receptor plays a role in lung injury and death caused by Influenza A in mice.PLoS pathogens · 2010Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Pneumonia caused by Streptococcus pneumoniae is a significant cause of morbidity and mortality during influenza virus epidemics. We had previously advanced the hypothesis that interactions of pneumococcus with the receptor for platelet activating factor (PAFR) in the lung were facilitated by antecedent influenza virus infection and play a major role in the pathogenesis of bacterial superinfections. Although influenza enhanced the adherence of pneumococci to respiratory epithelial cells in vitro, chemical or antibody-mediated blockade of the PAFR did not affect adherence. In agreement with these data, mice lacking PAFR had similar bacterial loads within the lung compartment when compared to heterozygous littermates and were not protected from secondary pneumococcal pneumonia after influenza. Lack of support for this hypothesis and the observation of enhanced inflammation during secondary pneumococcal pneumonia in mice lacking PAFR may moderate enthusiasm for treatment strategies targeting the interaction of bacteria with PAFR.
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Registered trials
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