ReviewMedical mycology2008
Discovering the secrets of the Candida albicans agglutinin-like sequence (ALS) gene family--a sticky pursuit.
Review in Medical mycology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 175 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
175 citing papers in PubMed, 357 citations in OpenAlex.
- Targeting Als3 adhesin of clinically relevant Candida species using natural carotenoids: an in-silico study.Molecular diversity · 2026Article
- Effect of subsequent passages on biofilm formation intensity, ALS genes expression, and cell surface hydrophobicity variability in clinical Candida albicans isolates.Scientific reports · 2026Article
- Exploring the Antifungal, Antibiofilm, and Wound Healing In Vitro Properties ofAntibiotics (Basel, Switzerland) · 2026Article
- Investigating the human-animal interface: Clinical and molecular features of oralOpen veterinary journal · 2026Article
- Article
- Context-dependent reprogramming ofFrontiers in microbiology · 2026Article
- Molecular mechanisms, pathogenesis and therapeutic advances ofFrontiers in cellular and infection microbiology · 2026Review
- StudyingPharmaceuticals (Basel, Switzerland) · 2025Review
- Xenosiderophore transporter gene expression and clade-specific filamentation in Candida auris killifish (Aphanius dispar) infection.Communications biology · 2025Article
- Integrative perspectives on glycosylation networks in fungi and oomycetes.Journal of microbiology (Seoul, Korea) · 2025Review
- A simple silicone elastomer colonization model highlights complexities ofJournal of medical microbiology · 2025Article
- Exploring the anti-biofilm and gene regulatory effects of anti-inflammatory drugs on Candida albicans.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Nanoparticles in the battle against Candida auris biofilms: current advances and future prospects.Drug delivery and translational research · 2025Review
- Development of Miniprotein-Type Inhibitors of Biofilm Formation inJournal of microbiology and biotechnology · 2025Article
- Article
- PCR-based CRISPR/Cas9 system for fluorescent tagging: A tool for studying Candida parapsilosis virulence.PloS one · 2025Article
- Effects of global change drivers on the expression of pathogenicity and stress genes in dryland soil fungi.mSphere · 2024Article
- Functional redundancy in Candida auris cell surface adhesins crucial for cell-cell interaction and aggregation.Nature communications · 2024Article
- Oral Microbiome: A Review of Its Impact on Oral and Systemic Health.Microorganisms · 2024Review
- Review
115 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The agglutinin-like sequence (ALS) family of Candida albicans includes eight genes that encode large cell-surface glycoproteins. The high degree of sequence relatedness between the ALS genes and the tremendous allelic variability often present in the same C. albicans strain complicated definition and characterization of the gene family. The main hypothesis driving ALS family research is that the genes encode adhesins, primarily involved in host-pathogen interactions. Although adhesive function has been demonstrated for several Als proteins, the challenge of studying putative adhesins in a highly adhesive organism like C. albicans has led to varying ideas about how best to pursue such investigations, and results that are sometimes contradictory. Recent analysis of alsdelta/alsdelta strains suggested roles for Als proteins outside of adhesion to host surfaces, and a broader scope of Als protein function than commonly believed. The availability and use of experimental methodologies to study C. albicans at the genomic level, and the ALS family en masse, have advanced knowledge of these genes and emphasized their importance in C. albicans biology and pathogenesis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.