ReviewJournal of molecular histology2007
Olfactory epithelium progenitors: insights from transgenic mice and in vitro biology.
Review in Journal of molecular histology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 97 citations in OpenAlex.
- Opposing expression pattern of opsin 3 and opsin 5 in the developing and adult nasal epithelium.Chemical senses · 2025Article
- Role and Mechanism of Olfactory Stem Cells in the Treatment of Olfactory Disorders.Stem cells international · 2025Review
- Study of the glial cytoarchitecture of the developing olfactory bulb of a shark using immunochemical markers of radial glia.Brain structure & function · 2022Article
- Olig2 regulates terminal differentiation and maturation of peripheral olfactory sensory neurons.Cellular and molecular life sciences : CMLS · 2020Article
- Human olfactory mesenchymal stromal cells co-expressing horizontal basal and ensheathing cell proteins in culture.Biomedica : revista del Instituto Nacional de Salud · 2020Article
- Activating a Reserve Neural Stem Cell Population In Vitro Enables Engraftment and Multipotency after Transplantation.Stem cell reports · 2019Article
- Transcriptional and Epigenetic Control of Mammalian Olfactory Epithelium Development.Molecular neurobiology · 2018Review
- FGF20-Expressing, Wnt-Responsive Olfactory Epithelial Progenitors Regulate Underlying Turbinate Growth to Optimize Surface Area.Developmental cell · 2018Article
- Potential role of CBX7 in regulating pluripotency of adult human pluripotent-like olfactory stem cells in stroke model.Cell death & disease · 2018Article
- Evaluation of Nestin Expression in the Developing and Adult Mouse Inner Ear.Stem cells and development · 2016Article
- Evidence for a Notch1-mediated transition during olfactory ensheathing cell development.Journal of anatomy · 2016Article
- mSWI/SNF (BAF) Complexes Are Indispensable for the Neurogenesis and Development of Embryonic Olfactory Epithelium.PLoS genetics · 2016Article
- Canonical Wnt Signaling Drives Tumor-Like Lesions from Sox2-Positive Precursors of the Murine Olfactory Epithelium.PloS one · 2016Article
- Intranasal Location and Immunohistochemical Characterization of the Equine Olfactory Epithelium.Frontiers in neuroanatomy · 2016Article
- Insm1 promotes neurogenic proliferation in delaminated otic progenitors.Mechanisms of development · 2015Article
- Primary Cilia on Horizontal Basal Cells Regulate Regeneration of the Olfactory Epithelium.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Horizontal Basal Cell-Specific Deletion of Pax6 Impedes Recovery of the Olfactory Neuroepithelium Following Severe Injury.Stem cells and development · 2015Article
- Odorant receptors regulate the final glomerular coalescence of olfactory sensory neuron axons.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Translational potential of olfactory mucosa for the study of neuropsychiatric illness.Translational psychiatry · 2015Review
- Injury in aged animals robustly activates quiescent olfactory neural stem cells.Frontiers in neuroscience · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The rodent olfactory epithelium (OE) is capable of prolonged neurogenesis, beginning at E10 in the embryo and continuing throughout adulthood. Significant progress has been made over the last 10 years in revealing the signals that drive induction, differentiation and survival of its Olfactory Receptor Neurons (ORNs). Our understanding of the identity of specific progenitors or precursors that respond to these signals is, however, less well developed, and the search is still on for the elusive, definitive multipotent neuro-glial OE "Stem cell". Here, we review several lines of evidence that support the existence of a heterogeneous population of neural and glial progenitors in the olfactory mucosa, and highlight the differences in the identity and activity of progenitors found in the embryonic and adult OE. In particular, we show how recent advances in mouse transgenesis, and in the development of in vitro assays of progenitor activity, have helped to demonstrate the existence of multiple classes of olfactory mucosa-based progenitors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.