ArticlePflugers Archiv : European journal of physiology2008
Locus coeruleus noradrenergic neurons and CO2 drive to breathing.
Article in Pflugers Archiv : European journal of physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02410954 (Transcranial Direct Current Stimulation), which is not on this map. Cited by 87 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Transcranial Direct Current Stimulation (tDCS) as a Treatment for Acute Fear
Who cites it
87 citing papers in PubMed, 201 citations in OpenAlex.
- Minocycline attenuates panicogenic responses in a COTranslational psychiatry · 2026Trial
- Effects of clonidine on breathing during sleep and susceptibility to central apnoea.Respiratory physiology & neurobiology · 2013Trial
- Periestropause enhances hypoxia-induced panic and microglial remodelling without altering respiratory control.Journal of neuroendocrinology · 2026Article
- Xylazine exacerbates fentanyl-induced respiratory depression and prevents rescue by naloxone in mice.Psychopharmacology · 2026Article
- The Rhythmic Embodied Perception Framework of breath, brain, and perception.Neuroscience of consciousness · 2026Review
- Neuroanatomical and neurochemical organization of brainstem and forebrain circuits involved in breathing regulation.Journal of neurophysiology · 2025Review
- Sudden Unexpected Death in Epilepsy: Central Respiratory Chemoreception.International journal of molecular sciences · 2025Review
- Respiratory Depression Associated with Opioids: A Narrative Review.Current treatment options in oncology · 2024Review
- Generation of locus coeruleus norepinephrine neurons from human pluripotent stem cells.Nature biotechnology · 2024Article
- Locus coeruleus noradrenaline depletion and its differential impact on COProgress in neuro-psychopharmacology & biological psychiatry · 2024Article
- Greater physical fitness (Acta physiologica (Oxford, England) · 2024Article
- Sex-specific threat responding and neuronal engagement in carbon dioxide associated fear and extinction: Noradrenergic involvement in female mice.Neurobiology of stress · 2024Article
- Loss-of-function of chemoreceptor neurons in the retrotrapezoid nucleus: What have we learned from it?Respiratory physiology & neurobiology · 2024Article
- Respiratory Dysfunction in Alzheimer's Disease-Consequence or Underlying Cause? Applying Animal Models to the Study of Respiratory Malfunctions.International journal of molecular sciences · 2024Review
- Article
- Greater physical fitness (Vo2Max) in healthy older adults associated with increased integrity of the Locus Coeruleus-Noradrenergic system.Research square · 2023Article
- Molecular profiling of COComparative biochemistry and physiology. Part A, Molecular & integrative physiology · 2023Article
- L-DOPA Improves Ventilation but Not the Ventilatory Response to Hypercapnia in a Reserpine Model of Parkinson's Disease.Brain sciences · 2023Article
- Review
- Article
27 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Locus coeruleus (LC) has been suggested as a CO(2) chemoreceptor site in mammals. In the present study, we assessed the role of LC noradrenergic neurons in the cardiorespiratory and thermal responses to hypercapnia. To selectively destroy LC noradrenergic neurons, we administered 6-hydroxydopamine (6-OHDA) bilaterally into the LC of male Wistar rats. Control animals had vehicle (ascorbic acid) injected (sham group) into the LC. Pulmonary ventilation (plethysmograph), mean arterial pressure (MAP), heart rate (HR), and body core temperature (T (c), data loggers) were measured followed by 60 min of hypercapnic exposure (7% CO(2) in air). To verify the correct placement and effectiveness of the chemical lesions, tyrosine hydroxylase immunoreactivity was performed. Hypercapnia caused an increase in pulmonary ventilation in all groups, which resulted from increases in respiratory frequency and tidal volume (V (T)) in sham-operated and 6-OHDA-lesioned groups. The hypercapnic ventilatory response was significantly decreased in 6-OHDA-lesioned rats compared with sham group. This difference was due to a decreased V (T) in 6-OHDA rats. LC chemical lesion or hypercapnia did not affect MAP, HR, and T (c). Thus, we conclude that LC noradrenergic neurons modulate hypercapnic ventilatory response but play no role in cardiovascular and thermal regulation under resting conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.