ReviewSeminars in immunopathology2007
Immunopathogenesis of IgAN.
Review in Seminars in immunopathology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 78 citations in OpenAlex.
- Guiding immunotherapy based on the oxford classification activity score in IgA nephropathy.Frontiers in endocrinology · 2026Article
- Rapidly Progressive Glomerulonephritis Due to IgA Nephropathy in a Patient With a Large Renal Mass.Cureus · 2024Article
- The prognostic value of the systemic immune inflammation index in patients with IgA nephropathy.Renal failure · 2024Article
- Propensity of IgA to self-aggregate via tailpiece cysteine-471 and treatment of IgA nephropathy using cysteamine.JCI insight · 2021Article
- Pathogenesis of IgA Nephropathy: Current Understanding and Implications for Development of Disease-Specific Treatment.Journal of clinical medicine · 2021Review
- The Glomerulus According to the Mesangium.Frontiers in medicine · 2021Review
- The Metalloproteinase ADAMTS5 Is Expressed by Interstitial Inflammatory Cells in IgA Nephropathy and Is Proteolytically Active on the Kidney Matrix.Journal of immunology (Baltimore, Md. : 1950) · 2020Article
- Immunity, microbiota and kidney disease.Nature reviews. Nephrology · 2019Review
- Location of glomerular immune deposits, not codeposition of immunoglobulin G, influences definitive renal outcomes in immunoglobulin A nephropathy.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2018Article
- Article
- The solution structures of native and patient monomeric human IgA1 reveal asymmetric extended structures: implications for function and IgAN disease.The Biochemical journal · 2015Article
- Rapidly progressive IgA nephropathy: a form of vasculitis or a complement-mediated disease?Clinical kidney journal · 2015Article
- Update on immunoglobulin A nephropathy, Part I: Pathophysiology.World journal of nephrology · 2015Article
- miR-744 enhances type I interferon signaling pathway by targeting PTP1B in primary human renal mesangial cells.Scientific reports · 2015Article
- Comparative proteomic analysis of renal tissue in IgA nephropathy with iTRAQ quantitative proteomics.Biomedical reports · 2014Article
- The extracellular matrix in the kidney: a source of novel non-invasive biomarkers of kidney fibrosis?Fibrogenesis & tissue repair · 2014Article
- The kinetics of glomerular deposition of nephritogenic IgA.PloS one · 2014Article
- Clinicopathological study of glomerular diseases associated with sarcoidosis: a multicenter study.Orphanet journal of rare diseases · 2013Article
- Disruption of Smad4 expression in T cells leads to IgA nephropathy-like manifestations.PloS one · 2013Article
- The IgA1 immune complex-mediated activation of the MAPK/ERK kinase pathway in mesangial cells is associated with glomerular damage in IgA nephropathy.Kidney international · 2012Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The defining hallmark of IgA nephropathy (IgAN) is deposition of polymeric IgA1 in the glomerular mesangium accompanied by a mesangial proliferative glomerulonephritis. The mechanisms involved in mesangial polymeric IgA1 deposition and the initiation of inflammatory glomerular injury remain unclear. This lack of a complete understanding of the pathogenesis of IgAN has meant that there is still no treatment known to modify mesangial deposition of IgA. Increasing evidence, however, supports the importance of IgA-containing immune complex formation as a pivotal factor driving mesangial IgA deposition and triggering of glomerular injury. A number of potentially important changes to the IgA1 molecule have been identified in IgAN, which may contribute to immune complex formation. These changes suggest that the polymeric IgA1 that deposits in IgA nephropathy is derived from mucosally primed plasma cells. The presence of this IgA in the circulation reflects displacement of mucosal B lineage cells to systemic sites and may be the result of mishoming of lymphocytes trafficking along the mucosa-bone marrow axis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.