Trial reportEuropean journal of clinical nutrition2009
The effect of different protein hydrolysate/carbohydrate mixtures on postprandial glucagon and insulin responses in healthy subjects.
Trial report in European journal of clinical nutrition, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 99 citations in OpenAlex.
- Protein Hydrolysates and Bioactive Peptides as Mediators of Blood Glucose-A Systematic Review and Meta-Analysis of Acute and Long-Term Studies.Nutrients · 2024Pooled it
- Pooled it
- Meal sugar-protein balance determines postprandial FGF21 response in humans.American journal of physiology. Endocrinology and metabolism · 2023Trial
- Influence of natural variations in eating rate and bolus properties on postprandial glucose and insulin responses in healthy adults.European journal of nutrition · 2026Article
- Deciphering the Molecular Bittercode in Potato Protein Hydrolysates through a Sensoproteomics Approach.Journal of agricultural and food chemistry · 2026Article
- High Doses of Exogenous Glucagon Stimulate Insulin Secretion and Reduce Insulin Clearance in Healthy Humans.Diabetes · 2024 · on this mapArticle
- Effect ofCurrent developments in nutrition · 2024Article
- Protein Hydrolysate from Underutilized Legumes: Unleashing the Potential for Future Functional Foods.Preventive nutrition and food science · 2023Review
- Expansion of human alpha-cell area is associated with a higher maximum body mass index before the onset of type 2 diabetes.Journal of diabetes · 2023Article
- In Vitro Assessment Methods for Antidiabetic Peptides from Legumes: A Review.Foods (Basel, Switzerland) · 2023Review
- Pea Protein-Derived Peptides Inhibit Hepatic Glucose Production via the Gluconeogenic Signaling in the AML-12 Cells.International journal of environmental research and public health · 2022Article
- How Healthy Are Non-Traditional Dietary Proteins? The Effect of Diverse Protein Foods on Biomarkers of Human Health.Foods (Basel, Switzerland) · 2022Review
- Effects of nutritional supplementation on glucose metabolism and insulin function among people with HIV initiating ART.BMC nutrition · 2021Article
- Core-Shell Microcapsules from Unpurified Legume Flours.ACS applied materials & interfaces · 2021Article
- The metabolic impact of small intestinal nutrient sensing.Nature communications · 2021Review
- Computational Analysis of Insulin-Glucagon Signalling Network: Implications of Bistability to Metabolic Homeostasis and Disease states.Scientific reports · 2019Article
- Physiological and therapeutic regulation of glucose homeostasis by upper small intestinal PepT1-mediated protein sensing.Nature communications · 2018Article
- Glycemic index of some local staples in Ghana.Food science & nutrition · 2017Article
- Glucagon action in the brain.Diabetologia · 2016Review
- Whey protein: The "whey" forward for treatment of type 2 diabetes?World journal of diabetes · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo study the effect of four protein hydrolysates from vegetable (pea, gluten, rice and soy) and two protein hydrolysates from animal origin (whey and egg) on glucagon and insulin responses. SUBJECTS/
methodsEight healthy normal-weight male subjects participated in this study. The study employed a repeated-measures design with Latin square randomization and single-blind trials. Protein hydrolysates used in this study (pea, rice, soy, gluten, whey and egg protein hydrolysate) consisted of 0.2 g hydrolysate per kg body weight (bw) and 0.2 g maltodextrin per kg bw and were compared to maltodextrin alone. Postprandial plasma glucose, glucagon, insulin and amino acids were determined over 2 h.
resultsAll protein hydrolysates induced an enhanced insulin secretion compared to maltodextrin alone and a correspondingly low plasma glucose response. A significant difference was observed in area under the curve (AUC) for plasma glucagon between protein hydrolysates and the maltodextrin control drink (P<0.05). Gluten protein hydrolysate induced the lowest glucagon response.
conclusionsHigh amino-acid-induced glucagon response does not necessarily go together with low insulin response. Protein hydrolysate source affects AUC for glucagon more profoundly than for insulin, although the protein load used in this study seemed to be at lower level for significant physiological effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.