ArticleEuropean journal of clinical nutrition2009
Dietary intake and status of folate and vitamin B12 and their association with homocysteine and cardiovascular disease in European populations.
Article in European journal of clinical nutrition, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 123 citations in OpenAlex.
- Associations of genetic determinants of serum vitamin B12 and folate concentrations with hay fever and asthma: a Mendelian randomization meta-analysis.European journal of clinical nutrition · 2018Pooled it
- Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway.Human molecular genetics · 2009Pooled it
- Trial
- Efficacy of 4.0 mg versus 0.4 mg Folic Acid Supplementation on the Reproductive Outcomes: A Randomized Controlled Trial.Nutrients · 2021Trial
- Homocysteine lowering by folate-rich diet or pharmacological supplementations in subjects with moderate hyperhomocysteinemia.Nutrients · 2013Trial
- Homocysteine, Nutrition, and Gut Microbiota: A Comprehensive Review of Current Evidence and Insights.Nutrients · 2025Review
- Biological, dietetic and pharmacological properties of vitamin BNPJ science of food · 2025Review
- Prevalent low Mediterranean diet adherence and low folate status in a Spanish Km 0 Mediterranean coast population.Current research in food science · 2025Article
- Article
- Adequate vitamin BThe British journal of nutrition · 2023Article
- Health-Promoting Ingredients in Goat's Milk and Fermented Goat's Milk Drinks.Animals : an open access journal from MDPI · 2023Article
- Dietary Antioxidants, Quality of Nutrition and Cardiovascular Characteristics among Omnivores, Flexitarians and Vegetarians in Poland-The Results of Multicenter National Representative Survey WOBASZ.Antioxidants (Basel, Switzerland) · 2023Article
- Health-Promoting Nutrients and Potential Bioaccessibility of Breads Enriched with Fresh Kale and Spinach.Foods (Basel, Switzerland) · 2022Article
- Design of Cereal Products Naturally Enriched in Folate from Barley Pearling By-Products.Nutrients · 2022Article
- Characteristics of Dietary Supplements with Folic Acid Available on the Polish Market.Nutrients · 2022Article
- Article
- Article
- Healthy adult gut microbiota sustains its own vitamin B12 requirement in anFrontiers in nutrition · 2022Article
- Associations of Serum Folate and Holotranscobalamin with Cardiometabolic Risk Factors in Rural and Urban Cameroon.Nutrients · 2021Article
- Prevalence and risk factors for hyperhomocysteinemia: a population-based cross-sectional study from Hunan, China.BMJ open · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesFolate and vitamin B12 have been suggested to play a role in chronic diseases like cardiovascular diseases. The objectives are to give an overview of the actual intake and status of folate and vitamin B12 in general populations in Europe, and to evaluate these in view of the current vitamin recommendations and the homocysteine concentration.
methodsSearches in Medline with 'folic acid', 'folate' and 'vitamin B12', 'B12' or 'cobalamin' as key words were combined with the names of the European countries. Populations between 18 and 65 years were included.
resultsSixty-three articles reporting on studies from 15 European countries were selected. Low folate intakes were observed in Norway, Sweden, Denmark and the Netherlands. Low intakes of vitamin B12 were not common and only seen in one small Greek study. In the countries with a low intake of folate, the recommended levels were generally not achieved, which was also reflected in the folate status. Vitamin B12 intake was not strongly associated with the vitamin B12 status, which can explain why in the Netherlands and Germany the vitamin B12 status was inadequate, despite sufficient intake levels. In countries with a low folate intake in particular, the Hcy concentration was higher than ideal.
conclusionsPopulations from the Nordic countries, the Netherlands, Germany and Greece may need to improve their intakes of folic acid, B12 or both to either meet the recommendations or to optimize their statuses. This could be achieved via a food-based approach, food fortification or supplements.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.