ArticleJournal of clinical virology : the official publication of the Pan American Society for Clinical Virology2007
Prospective study of Human Bocavirus (HBoV) infection in a pediatric university hospital in Germany 2005/2006.
Article in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 72 citations in OpenAlex.
- Twenty years of human bocavirus research: from an unculturable virus of unclear pathogenicity to a culturable human pathogen and gene therapy vector candidate.Clinical microbiology reviews · 2025Review
- The Burden of Human Bocavirus 1 in Hospitalized Children With Respiratory Tract Infections.Journal of the Pediatric Infectious Diseases Society · 2023Article
- Human bocavirus 2 detected in Rattus norvegicus feces in China.Archives of virology · 2022Article
- Characteristics of human parainfluenza virus type 4 infection in hospitalized children in Korea.Pediatrics international : official journal of the Japan Pediatric Society · 2020Article
- Human Parvoviruses.Clinical microbiology reviews · 2017Review
- Human bocavirus: Current knowledge and future challenges.World journal of gastroenterology · 2016Review
- Atypical presentation of human bocavirus: Severe respiratory tract infection complicated with encephalopathy.Journal of medical virology · 2015Article
- Human bocavirus: lessons learned to date.Pathogens (Basel, Switzerland) · 2013Review
- Human bocavirus and other respiratory viral infections in a 2-year cohort of hospitalized children.Journal of medical virology · 2012Article
- Article
- PCR improves diagnostic yield from lung aspiration in Malawian children with radiologically confirmed pneumonia.PloS one · 2011Article
- Human bocavirus in children with respiratory tract infection in Shanghai: a retrospective study.World journal of pediatrics : WJP · 2010Article
- The human bocaviruses: a review and discussion of their role in infection.Clinics in laboratory medicine · 2009Review
- Simultaneous detection of human bocavirus and adenovirus by multiplex real-time PCR in a Belgian paediatric population.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2009Article
- Article
- Low prevalence of human metapneumovirus and human bocavirus in adult immunocompromised high risk patients suspected to suffer from Pneumocystis pneumonia.The Journal of infection · 2009Article
- Polyomaviruses KI and WU in children with respiratory tract infection.Archives of virology · 2009Article
- Clinical and epidemiological aspects of human bocavirus infection.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2008Review
- Evidence of human bocavirus circulating in children and adults, Cleveland, Ohio.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2008Article
- Absence of Melaka-virus in European children with respiratory disease.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2008Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHuman Bocavirus (HBoV), a new species of the genus parvovirus newly detected in 2005, seems to be a worldwide distributed pathogen among children with respiratory tract infection (prevalence 2%-18%). Recently published retrospective studies and one prospective birth cohort study suggest that HBoV-primary infection occurs in infants.
methodsProspective single center study over one winter season (November 2005-May 2006) with hospitalized children without age restriction using PCR-based diagnostic methods.
resultsHBoV DNA was detected in 11 (2.8%) of 389 nasopharyngeal aspirates from symptomatic hospitalized children (median age 9.0 months; range: 3-17 months). RSV, HMPV, HCoV, and Influenza B were detected in 13.9% (n=54), 5.1% (n=20), 2.6% (n=10), and 1.8% (n=7), respectively. There was no influenza A DNA detected in any of the specimens. The clinical diagnoses were acute wheezing (bronchitis) in four patients, radiologically confirmed pneumonia in six patients (55%) and croup syndrome in one patient. In five to six patients with pneumonia, HBoV was the only pathogen detected. While no patient had to be mechanically ventilated, 73% needed oxygen supplementation. In four (36.4%) patients at least one other viral pathogen was found (plus RSV n=3; 27.3%; Norovirus n=1; 9.1%).
conclusionHBoV causes severe respiratory tract infections in infants and young children. Its role as a copathogen and many other open questions has to be defined in further prospective studies.
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