ArticleDevelopmental biology2007
GATA-2 functions downstream of BMPs and CaM KIV in ectodermal cells during primitive hematopoiesis.
Article in Developmental biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- SpatialQuery: scalable discovery and molecular characterization of multicellular motifs from spatial omics data.bioRxiv : the preprint server for biology · 2026Article
- Human GATA2 mutations and hematologic disease: how many paths to pathogenesis?Blood advances · 2020Review
- Extracellular vesicle cross-talk between pulmonary artery smooth muscle cells and endothelium during excessive TGF-β signalling: implications for PAH vascular remodelling.Cell communication and signaling : CCS · 2019Article
- The role of GATA2 in lethal prostate cancer aggressiveness.Nature reviews. Urology · 2017Review
- Tril targets Smad7 for degradation to allow hematopoietic specification in Xenopus embryos.Development (Cambridge, England) · 2016Article
- Expression pattern of bcar3, a downstream target of Gata2, and its binding partner, bcar1, during Xenopus development.Gene expression patterns : GEP · 2016Article
- GATA2 regulates Wnt signaling to promote primitive red blood cell fate.Developmental biology · 2015Article
- A GATA2/3 gene potentially involved in larval shell formation of the Pacific oyster Crassostrea gigas.Development genes and evolution · 2015Article
- Epigenetic and genetic mechanisms in red cell biology.Current opinion in hematology · 2014Review
- Expression and localization of Rdd proteins in Xenopus embryo.Anatomy & cell biology · 2014Article
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- VEGFA-dependent and -independent pathways synergise to drive Scl expression and initiate programming of the blood stem cell lineage in Xenopus.Development (Cambridge, England) · 2013Article
- Article
- Master regulatory GATA transcription factors: mechanistic principles and emerging links to hematologic malignancies.Nucleic acids research · 2012Review
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- Article
- The ERGonomics of hematopoietic stem cell self-renewal.Genes & development · 2011Article
- Microarray identification of novel downstream targets of FoxD4L1/D5, a critical component of the neural ectodermal transcriptional network.Developmental dynamics : an official publication of the American Association of Anatomists · 2010Article
- Cell communication with the neural plate is required for induction of neural markers by BMP inhibition: evidence for homeogenetic induction and implications for Xenopus animal cap and chick explant assays.Developmental biology · 2009Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
In Xenopus, primitive blood originates from the mesoderm, but extrinsic signals from the ectoderm are required during gastrulation to enable these cells to differentiate as erythrocytes. The nature of these signals, and how they are transcriptionally regulated, is not well understood. We have previously shown that bone morphogenetic proteins (BMPs) are required to signal to ectodermal cells to generate secondary non-cell-autonomous signal(s) necessary for primitive erythropoiesis, and that calmodulin-dependent protein kinase IV (CaM KIV) antagonizes BMP signaling. The current studies demonstrate that Gata-2 functions downstream of BMP receptor activation in these same cells, and is a direct target for antagonism by CaM KIV. We show, using loss of function analysis in whole embryos and in explants, that ectodermal Gata-2 is required for primitive erythropoiesis, and that BMP signals cannot rescue blood defects caused by ectoderm removal or loss of ectodermal GATA-2. Furthermore, we provide evidence that acetylation of GATA-2 is required for its function in primitive blood formation in vivo. Our data support a model in which Gata-2 is a transcriptional target downstream of BMPs within ectodermal cells, while activation of the CaM KIV signaling pathway alters GATA-2 function posttranslationally, by inhibiting its acetylation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.