ArticleDevelopmental biology2007
A G(s)-linked receptor maintains meiotic arrest in mouse oocytes, but luteinizing hormone does not cause meiotic resumption by terminating receptor-G(s) signaling.
Article in Developmental biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Discovery of Small Molecule Ligands Targeting Orphan G Protein-Coupled Receptors GPR3, GPR6, and GPR12.Journal of medicinal chemistry · 2026Review
- Luteinizing hormone stimulates ingression of mural granulosa cells within the mouse preovulatory follicle†.Biology of reproduction · 2024Article
- In vitro maturation (IVM) of human immature oocytes: is it still relevant?Reproductive biology and endocrinology : RB&E · 2023Review
- Making a good egg: human oocyte health, aging, and in vitro development.Physiological reviews · 2023Review
- High cGMP and low PDE3A activity are associated with oocyte meiotic incompetence.Cell cycle (Georgetown, Tex.) · 2019Article
- GPR3, GPR6, and GPR12 as novel molecular targets: their biological functions and interaction with cannabidiol.Acta pharmacologica Sinica · 2019Review
- Immature Oocyte for Fertility Preservation.Frontiers in endocrinology · 2019Review
- Cyclin B2 can compensate for Cyclin B1 in oocyte meiosis I.The Journal of cell biology · 2018Article
- Luteinizing hormone signaling phosphorylates and activates the cyclic GMP phosphodiesterase PDE5 in mouse ovarian follicles, contributing an additional component to the hormonally induced decrease in cyclic GMP that reinitiates meiosis.Developmental biology · 2018Article
- Regulation of Mammalian Oocyte Meiosis by Intercellular Communication Within the Ovarian Follicle.Annual review of physiology · 2017Review
- Signaling-Mediated Regulation of Meiotic Prophase I and Transition During Oogenesis.Results and problems in cell differentiation · 2017Review
- Mice lacking GPR3 receptors display late-onset obese phenotype due to impaired thermogenic function in brown adipose tissue.Scientific reports · 2015Article
- Redistribution of Gαs in mouse salivary glands following β-adrenergic stimulation.Archives of oral biology · 2015Article
- Hormonal control of mammalian oocyte meiosis at diplotene stage.Cellular and molecular life sciences : CMLS · 2012Review
- Prophase I arrest and progression to metaphase I in mouse oocytes: comparison of resumption of meiosis and recovery from G2-arrest in somatic cells.Molecular human reproduction · 2010Review
- Review
- Cyclic GMP from the surrounding somatic cells regulates cyclic AMP and meiosis in the mouse oocyte.Development (Cambridge, England) · 2009Article
- Microinjection of follicle-enclosed mouse oocytes.Methods in molecular biology (Clifton, N.J.) · 2009Article
- Luteinizing hormone causes MAP kinase-dependent phosphorylation and closure of connexin 43 gap junctions in mouse ovarian follicles: one of two paths to meiotic resumption.Development (Cambridge, England) · 2008Article
- The Xenopus laevis isoform of G protein-coupled receptor 3 (GPR3) is a constitutively active cell surface receptor that participates in maintaining meiotic arrest in X. laevis oocytes.Molecular endocrinology (Baltimore, Md.) · 2008Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The maintenance of meiotic prophase arrest in fully grown vertebrate oocytes depends on the activity of a G(s) G-protein that activates adenylyl cyclase and elevates cAMP, and in the mouse oocyte, G(s) is activated by a constitutively active orphan receptor, GPR3. To determine whether the action of luteinizing hormone (LH) on the mouse ovarian follicle causes meiotic resumption by inhibiting GPR3-G(s) signaling, we examined the effect of LH on the localization of Galpha(s). G(s) activation in response to stimulation of an exogenously expressed beta(2)-adrenergic receptor causes Galpha(s) to move from the oocyte plasma membrane into the cytoplasm, whereas G(s) inactivation in response to inhibition of the beta(2)-adrenergic receptor causes Galpha(s) to move back to the plasma membrane. However, LH does not cause a change in Galpha(s) localization, indicating that LH does not act by terminating receptor-G(s) signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.