ArticlePharmaceutical research2007
Chemical groups that adhere to the surfaces of living malignant cells.
Article in Pharmaceutical research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Characterization of anomalous movements of spherical living cells on a silicon dioxide glassy substrate.Biomicrofluidics · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe determined the adhesion of particles with phenyl, carboxylic acid (COOH), amine, dialkyl phosphonate, ester, and hydroxyl groups to malignant and nonmalignant cells, in order to better design drug delivery systems (DDS) for malignant cells.
methodsLiving mouse melanoma skin (B16F10) and noncancerous mouse fibroblast (L929) cells, and an Atomic Force Microscope were used to determine the adhesion strengths.
resultsThe measurement of the particles against B16F10 cells showed that COOH had the highest average maximum adhesion force (<F (admax)>) and a large standard deviation (std), and phenyl had the lowest <F (admax)> and a lower std. The high <F (admax)> and std suggested that COOH was binding the strongest to malignant cells, and to groups overexpressed on malignant cells. In the case of L929 cells, <F (admax)> of phenyl and COOH were higher and lower, respectively, than those of the B16F10 cells. Additionally, Phenyl and COOH gave a lower std than that for the B16F10 cells. These results suggest that the lower binding of COOH to the nonmalignant cells was due to the lower number of groups that were overexpressed in the malignant cells.
conclusionsOur results suggest that COOH is the best group for malignant cell targeting DDS systems.
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Registered trials
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