ArticlePloS one2007
Linkage group selection: towards identifying genes controlling strain specific protective immunity in malaria.
Article in PloS one, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Bulk segregant linkage mapping for rodent and human malaria parasites.Parasitology international · 2022Review
- Pfs47 as a Malaria Transmission-Blocking Vaccine Target.The American journal of tropical medicine and hygiene · 2022Article
- The power and promise of genetic mapping from Plasmodium falciparum crosses utilizing human liver-chimeric mice.Communications biology · 2021Article
- Differing patterns of selection and geospatial genetic diversity within two leading Plasmodium vivax candidate vaccine antigens.PLoS neglected tropical diseases · 2014Article
- Quantifying variation in the potential for antibody-mediated apparent competition among nine genotypes of the rodent malaria parasite Plasmodium chabaudi.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2013Article
- Optimized protocols for improving the likelihood of cloning recombinant progeny from Plasmodium yoelii genetic crosses.Experimental parasitology · 2013Article
- The contribution of Plasmodium chabaudi to our understanding of malaria.Trends in parasitology · 2012Review
- Linkage maps from multiple genetic crosses and loci linked to growth-related virulent phenotype in Plasmodium yoelii.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Protocol for production of a genetic cross of the rodent malaria parasites.Journal of visualized experiments : JoVE · 2011Article
- Strain-specific immunity induced by immunization with pre-erythrocytic stages of Plasmodium chabaudi.Parasite immunology · 2011Article
- Limited polymorphism of the Plasmodium vivax merozoite surface protein 1 gene in isolates from Turkey.The American journal of tropical medicine and hygiene · 2010Article
- Allele frequency-based and polymorphism-versus-divergence indices of balancing selection in a new filtered set of polymorphic genes in Plasmodium falciparum.Molecular biology and evolution · 2010Article
- Experimental evolution, genetic analysis and genome re-sequencing reveal the mutation conferring artemisinin resistance in an isogenic lineage of malaria parasites.BMC genomics · 2010Article
- Hundreds of microsatellites for genotyping Plasmodium yoelii parasites.Molecular and biochemical parasitology · 2009Article
- Gene encoding erythrocyte binding ligand linked to blood stage multiplication rate phenotype in Plasmodium yoelii yoelii.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
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3 authors.
Funding
Abstract
Protective immunity against blood infections of malaria is partly specific to the genotype, or strain, of the parasites. The target antigens of Strain Specific Protective Immunity are expected, therefore, to be antigenically and genetically distinct in different lines of parasite. Here we describe the use of a genetic approach, Linkage Group Selection, to locate the target(s) of Strain Specific Protective Immunity in the rodent malaria parasite Plasmodium chabaudi chabaudi. In a previous such analysis using the progeny of a genetic cross between P. c. chabaudi lines AS-pyr1 and CB, a location on P. c. chabaudi chromosome 8 containing the gene for merozoite surface protein-1, a known candidate antigen for Strain Specific Protective Immunity, was strongly selected. P. c. chabaudi apical membrane antigen-1, another candidate for Strain Specific Protective Immunity, could not have been evaluated in this cross as AS-pyr1 and CB are identical within the cell surface domain of this protein. Here we use Linkage Group Selection analysis of Strain Specific Protective Immunity in a cross between P. c. chabaudi lines CB-pyr10 and AJ, in which merozoite surface protein-1 and apical membrane antigen-1 are both genetically distinct. In this analysis strain specific immune selection acted strongly on the region of P. c. chabaudi chromosome 8 encoding merozoite surface protein-1 and, less strongly, on the P. c. chabaudi chromosome 9 region encoding apical membrane antigen-1. The evidence from these two independent studies indicates that Strain Specific Protective Immunity in P. c. chabaudi in mice is mainly determined by a narrow region of the P. c. chabaudi genome containing the gene for the P. c. chabaudi merozoite surface protein-1 protein. Other regions, including that containing the gene for P. c. chabaudi apical membrane antigen-1, may be more weakly associated with Strain Specific Protective Immunity in these parasites.
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