ArticleInternational journal of biological sciences2007
High level glucose increases mutagenesis in human lymphoblastoid cells.
Article in International journal of biological sciences, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 39 citations in OpenAlex.
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- Local and Systemic Immune Dysregulation Alters Glioma Growth in Hyperglycemic Mice.Clinical cancer research : an official journal of the American Association for Cancer Research · 2020Article
- Sera Anti-P53 Antibody Provides New Information Which Explains the Link Between Diabetes and Cancer.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Obesity, DNA Damage, and Development of Obesity-Related Diseases.International journal of molecular sciences · 2019Review
- Incidence and relative risk for developing cancers in women with gestational diabetes mellitus: a nationwide cohort study in Taiwan.BMJ open · 2019Article
- Aberrant DNA damage response and DNA repair pathway in high glucose conditions.Journal of cancer research updates · 2018Article
- Dynamic cellular and molecular modulations of diabetes mediated head and neck carcinogenesis.Oncotarget · 2015Article
- Evidence for DNA damage as a biological link between diabetes and cancer.Chinese medical journal · 2015Review
- Diabetes and its link with cancer: providing the fuel and spark to launch an aggressive growth regime.BioMed research international · 2015Review
- Oxidative DNA damage in diabetic and mild gestational hyperglycemic pregnant women.Diabetology & metabolic syndrome · 2015Article
- Cancer biology in diabetes.Journal of diabetes investigation · 2014Review
- The impact of thiamine treatment in the diabetes mellitus.Journal of clinical medicine research · 2012Article
- Genomic instability in patients with type 2 diabetes mellitus on hemodialysis.Revista brasileira de hematologia e hemoterapia · 2012Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epidemiological data have suggested an increased cancer rates in diabetic patients, for which the underlying mechanism is poorly understood. We studied whether high level of glucose (HG) treatment that mimic the hyperglycemic condition in diabetes mellitus is mutagenic. Mutagenesis studies were carried out at both hypoxanthine phosphoribosyltransferase (hprt) and thymidine kinase (tk) loci. Role of p53 in HG-induced mutagenesis was also investigated by using human lymphoblastoid cell lines derived from same donor but differs in p53 statuses; TK6 has wild-type p53, NH32 has null p53, and WTK1 has mutant p53 (ile237). In addition, we studied the influence of antioxidant treatment on HG-induced mutagenesis. Mutation fractions at both loci increased significantly in all three lines at 21 and 28 days after HG treatments. At tk locus, the increase of a class of mutants with normal growth rate is mainly responsible for the overall increased mutant fraction. Compared to TK6 cells, both NH32 and WTK1 cells showed an early onset of mutagenesis. Treatment of cells with antioxidant N-acetyl-L-cysteine partially reduced HG induced mutagenesis. This study is the first to indicate that HG is able to induce gene mutation which may be one of the important mechanisms of diabetes-associated carcinogenesis.
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