ReviewJournal of endocrinological investigation
Looking beyond low bone mineral density: multiple insufficiency fractures in a woman with post-menopausal osteoporosis on alendronate therapy.
Review in Journal of endocrinological investigation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 55 citations in OpenAlex.
- Long-term administration of quarterly IV ibandronate is effective and well tolerated in postmenopausal osteoporosis: 5-year data from the DIVA study long-term extension.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2012Trial
- Spectroscopic markers of bone quality in alendronate-treated postmenopausal women.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2009Trial
- A low-energy femoral shaft fracture from performing a yoga posture.BMJ case reports · 2015Article
- Risk factors associated with sacral stress fractures: a systematic review.The Journal of manual & manipulative therapy · 2015Review
- Adipose tissue dysfunction and its effects on tumor metabolism.Hormone molecular biology and clinical investigation · 2015Review
- Review: epidemiology and pathophysiology of atypical femur fractures.Current osteoporosis reports · 2014Review
- Article
- Do bisphosphonates cause femoral insufficiency fractures?Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2012Review
- Management of osteoporosis among the elderly with other chronic medical conditions.Drugs & aging · 2012Review
- Atypical femur fractures: a review of the evidence and its implication to clinical practice.Therapeutic advances in musculoskeletal disease · 2011Article
- Review
- Subtrochanteric fractures after long-term treatment with bisphosphonates: a European Society on Clinical and Economic Aspects of Osteoporosis and Osteoarthritis, and International Osteoporosis Foundation Working Group Report.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2011Review
- Cumulative alendronate dose and the long-term absolute risk of subtrochanteric and diaphyseal femur fractures: a register-based national cohort analysis.The Journal of clinical endocrinology and metabolism · 2010Article
- Bisphosphonates for the treatment of osteoporosis: insights for clinicians.Therapeutic advances in chronic disease · 2010Article
- Atypical subtrochanteric and femoral shaft fractures and possible association with bisphosphonates.Current osteoporosis reports · 2010Review
- Fragility fractures of the hip and femur: incidence and patient characteristics.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2010Article
- Clodronic acid formulations available in Europe and their use in osteoporosis: a review.Clinical drug investigation · 2009Review
- Low-energy femoral fractures associated with the long-term use of bisphosphonates: a case series from a Swiss university hospital.Drug safety · 2009Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insufficiency fractures occur most commonly in the pelvic girdle and in the sacrum, followed by the tibia and the femoral neck. Insufficiency fractures of the femoral diaphyses are rare, with only few reported cases in the literature. The strongest associations exist with untreated osteoporosis. We describe an unusual case of multiple insufficiency fractures in a 73-yr-old Chinese woman who presented with a 10-month history of bilateral groin pain and difficulty with walking in the absence of trauma, diagnosed 18 months following the commencement of anti-resorptive therapy with alendronate. The pathogenesis of such insufficiency fractures is poorly understood, but next to low bone mineral density and micro-architectural damage likely involves other components such as changes in bone turnover and patient-related factors (e.g. non-compliance). This case report and review of the literature draws attention to some of the challenges in the diagnosis and management of such rare insufficiency fractures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.