ArticleProceedings of the National Academy of Sciences of the United States of America2007
Maintenance of imprinting and nuclear architecture in cycling cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Genome-wide analysis reveals no evidence of trans chromosomal regulation of mammalian immune development.PLoS genetics · 2018Article
- Pairing and anti-pairing: a balancing act in the diploid genome.Current opinion in genetics & development · 2016Review
- The dynamic architectural and epigenetic nuclear landscape: developing the genomic almanac of biology and disease.Journal of cellular physiology · 2014Review
- Physical origin of the contact frequency in chromosome conformation capture data.Biophysical journal · 2013Article
- Dynamic trans interactions in yeast chromosomes.PloS one · 2013Article
- Combined fluorescent-chromogenic in situ hybridization for identification and laser microdissection of interphase chromosomes.PloS one · 2013Article
- Visualization of the spatial positioning of the SNRPN, UBE3A, and GABRB3 genes in the normal human nucleus by three-color 3D fluorescence in situ hybridization.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2012Article
- The influence of DNA sequence on epigenome-induced pathologies.Epigenetics & chromatin · 2012Article
- Pairing of homologous regions in the mouse genome is associated with transcription but not imprinting status.PloS one · 2012Article
- Identification of genes that promote or antagonize somatic homolog pairing using a high-throughput FISH-based screen.PLoS genetics · 2012Article
- Neuron-specific impairment of inter-chromosomal pairing and transcription in a novel model of human 15q-duplication syndrome.Human molecular genetics · 2011Article
- Changed genome heterochromatinization upon prolonged activation of the Raf/ERK signaling pathway.PloS one · 2010Article
- Activation of estrogen-responsive genes does not require their nuclear co-localization.PLoS genetics · 2010Article
- Interchromosomal association and gene regulation in trans.Trends in genetics : TIG · 2010Review
- Chromosome territories.Cold Spring Harbor perspectives in biology · 2010Review
- Association between active genes occurs at nuclear speckles and is modulated by chromatin environment.The Journal of cell biology · 2008Article
- A journey into the nucleus. Conference on Nuclear Structure and Dynamics.EMBO reports · 2008Article
- Spatial quantitative analysis of fluorescently labeled nuclear structures: problems, methods, pitfalls.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2008Review
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dynamic gene repositioning has emerged as an additional level of epigenetic gene regulation. An early example was the report of a transient, spatial convergence (< or =2 microm) of oppositely imprinted regions ("kissing"), including the Angelman syndrome/Prader-Willi syndrome (AS/PWS) locus and the Beckwith-Wiedemann syndrome locus in human lymphocytes during late S phase. It was argued that kissing is required for maintaining opposite imprints in cycling cells. Employing 3D-FISH with a BAC contig covering the AS/PWS region, light optical, serial sectioning, and quantitative 3D-image analysis, we observed that both loci always retained a compact structure and did not form giant loops. Three-dimensional distances measured among various, homologous AS/PWS segments in 393 human lymphocytes, 132 human fibroblasts, and 129 lymphoblastoid cells from Gorilla gorilla revealed a wide range of distances at any stage of interphase and in G(0). At late S phase, 4% of nuclei showed distances < or =2 microm, 49% showed distances >6 microm, and 18% even showed distances >8 microm. A similar distance variability was found for Homo sapiens (HSA) 15 centromeres in a PWS patient with a deletion of the maternal AS/PWS locus and for the Beckwith-Wiedemann syndrome loci in human lymphocytes. A transient kiss during late S phase between loci widely separated at other stages of the cell cycle seems incompatible with known global constraints of chromatin movements in cycling cells. Further experiments suggest that the previously observed convergence of AS/PWS loci during late S phase was most likely a side effect of the convergence of nucleolus organizer region-bearing acrocentric human chromosomes, including HSA 15.
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