ArticleBMC cancer2007
TGFB1 and TGFBR1 polymorphisms and breast cancer risk in the Nurses' Health Study.
Article in BMC cancer, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 5 of them syntheses that pooled it.
What it found
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Who cites it
25 citing papers in PubMed, 5 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Association between Int7G24A rs334354 polymorphism and cancer risk: a meta-analysis of case-control studies.Scientific reports · 2015Pooled it
- Association of TGF-β1 -509C/T polymorphisms with breast cancer risk: evidence from an updated meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- Association between TGFBR1 polymorphisms and cancer risk: a meta-analysis of 35 case-control studies.PloS one · 2012Pooled it
- Lack of significant association between TGF-β1-590C/T polymorphism and breast cancer risk: a meta-analysis.Medical oncology (Northwood, London, England) · 2011Pooled it
- TGFBR1*6A/9A polymorphism and cancer risk: a meta-analysis of 13,662 cases and 14,147 controls.Molecular biology reports · 2010Pooled it
- TGFBR1*6A as a modifier of breast cancer risk and progression: advances and future prospects.NPJ breast cancer · 2022Review
- Role and clinical significance of TGF‑β1 and TGF‑βR1 in malignant tumors (Review).International journal of molecular medicine · 2021Review
- Association ofCancers · 2020Article
- Effects of Two Common Promoter Polymorphisms of Transforming Growth Factor-β1 on Breast Cancer Risks in Ahvaz, West South of Iran.Iranian journal of cancer prevention · 2016Article
- TGF-β1 C-509T and T869C polymorphisms and cancer risk: a meta analysis.International journal of clinical and experimental medicine · 2015Article
- Transforming growth factor beta1 (TGFβ1) polymorphisms and breast cancer risk.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Associations between genetic variants in the TGF-β signaling pathway and breast cancer risk among Hispanic and non-Hispanic white women.Breast cancer research and treatment · 2013Article
- The L10P polymorphism and serum levels of transforming growth factor β1 in human breast cancer.International journal of molecular sciences · 2013Article
- Strong impact of TGF-β1 gene polymorphisms on breast cancer risk in Indian women: a case-control and population-based study.PloS one · 2013Article
- Debate about TGFBR1 and the susceptibility to colorectal cancer.World journal of gastrointestinal oncology · 2012Article
- A functional polymorphism of TGFBR2 is associated with risk of breast cancer with ER(+), PR(+), ER(+)PR(+) and HER2(-) expression in women.Oncology letters · 2011Article
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- Radiation carcinogenesis in context: how do irradiated tissues become tumors?Health physics · 2009Review
- Transforming growth factor-(beta)s and mammary gland involution; functional roles and implications for cancer progression.Journal of mammary gland biology and neoplasia · 2009Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundTransforming growth factor beta 1 (TGFB1) forms a signaling complex with transforming growth factor beta receptors 1 and 2 and has been described as both a tumor suppressor and tumor promoter. Single nucleotide polymorphisms in TGFB1 and a microsatellite in TGFBR1 have been investigated for association with risk of breast cancer, with conflicting results.
methodsWe examined polymorphisms in the promoter region of the TGFB1 gene as well as the TGFBR1*6A microsatellite in the Nurses' Health Study cohort.
resultsNo overall associations between the L10P polymorphism of TGFB1 or the TGFBR1 microsatellite were detected. However, we observed an inverse association between the -509 C/T polymorphism of TGFB1 (p-trend = 0.04), which was stronger and more significant among women with estrogen receptor positive breast cancer.
conclusionPolymorphisms in the promoter region of TGFB1 are not likely to be associated with large increases in breast cancer risk overall among Caucasian women.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.