ArticleJournal of thrombosis and haemostasis : JTH2007
Heritability of flow-mediated dilation: a twin study.
Article in Journal of thrombosis and haemostasis : JTH, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- Interaction of genetic background and exercise training intensity on endothelial function in mouse aorta.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2020Article
- Strain survey and genetic analysis of vasoreactivity in mouse aorta.Physiological genomics · 2016Article
- Genetic Research and Women's Heart Disease: a Primer.Current atherosclerosis reports · 2016Review
- Genetic Regulation of Endothelial Vasomotor Function.Frontiers in physiology · 2016Review
- Promoter methylation of glucocorticoid receptor gene is associated with subclinical atherosclerosis: A monozygotic twin study.Atherosclerosis · 2015Article
- Endothelial Dysfunction is Associated with Occult Coronary Artery Disease Detected by Positron Emission Tomography.IJC metabolic & endocrine · 2014Article
- Association between ideal cardiovascular health and carotid intima-media thickness: a twin study.Journal of the American Heart Association · 2014Article
- Monoamine oxidase A genotype, childhood trauma, and subclinical atherosclerosis: a twin study.Psychosomatic medicine · 2013Article
- Endothelial dysfunction is associated with left ventricular mass (assessed using MRI) in an adult population (MESA).Journal of human hypertension · 2011Article
- A twin study of metabolic syndrome and autonomic tone.Journal of cardiovascular electrophysiology · 2009Article
- Common genetic contributions to depressive symptoms and inflammatory markers in middle-aged men: the Twins Heart Study.Psychosomatic medicine · 2009Article
- Depressive symptoms and heart rate variability: evidence for a shared genetic substrate in a study of twins.Psychosomatic medicine · 2008Article
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundEndothelial dysfunction assessed by brachial artery flow-mediated dilation (FMD) is a marker for early atherosclerotic vascular disease and future cardiovascular events.
objectiveTo estimate the heritability of brachial artery FMD using a twin design.
methodsWe estimated the heritability of FMD using 94 middle-aged male twin pairs. FMD was measured by ultrasound, and traditional coronary heart disease risk factors were measured. Genetic modeling techniques were used to determine the relative contributions of genes and environment to the variation in FMD.
resultsThe mean age of the twin participants was 54.9 +/- 2.8 years. The mean FMD was 0.047 +/- 0.030. The intraclass correlation coefficient was higher in MZ twins [0.38, 95% confidence interval (CI) 0.32-0.43] than in DZ twins (0.19, 95% CI 0.11-0.26), suggesting a role of genetic influence in FMD variation. Structural equation modeling showed that both genetic and unique environmental factors contributed significantly to the variation in FMD. The crude FMD heritability was 0.37 (95% CI 0.15-0.54). After adjustment for traditional cardiovascular risk factors, including age, total cholesterol, blood pressure, and body mass index, the heritability of FMD was 39% (95% CI 0.18-0.56). The remaining variation in FMD could be explained by individual-specific environment.
conclusionThis is the first study using twins to estimate the relative contributions of genetics and environment to the variation in FMD in a US population. Our results demonstrate a moderate genetic effect on brachial artery FMD, independent of traditional coronary risk factors. Our data also highlight the importance of unique environment on the variability in FMD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.