ArticleImmunology2007
Interferon-gamma-dependent inhibition of late allergic airway responses and eosinophilia by CD8+ gammadelta T cells.
Article in Immunology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Phagocytic aberrations in macrophages in asthma: a mechanistic systematic review integratingFrontiers in immunology · 2026Pooled it
- γδ T Lymphocytes in Asthma: a Complicated Picture.Archivum immunologiae et therapiae experimentalis · 2021Review
- Characterisation of a murine model of the late asthmatic response.Respiratory research · 2017Article
- The sickle cell mouse lung: proinflammatory and primed for allergic inflammation.Translational research : the journal of laboratory and clinical medicine · 2015Article
- γδT cells suppress inflammation and disease during rhinovirus-induced asthma exacerbations.Mucosal immunology · 2013Article
- Solute carrier 11A1 is expressed by innate lymphocytes and augments their activation.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- The immune response to parasitic helminths of veterinary importance and its potential manipulation for future vaccine control strategies.Parasitology research · 2012Review
- Eosinophils in glioblastoma biology.Journal of neuroinflammation · 2012Review
- γδ T Lymphocytes Coordinate Eosinophil Influx during Allergic Responses.Frontiers in pharmacology · 2012Article
- Association between reduced copy-number at T-cell receptor gamma (TCRgamma) and childhood allergic asthma: A possible role for somatic mosaicism.Mutation research · 2010Article
- Pathogenesis of allergic airway inflammation.Current allergy and asthma reports · 2010Review
- Polysaccharides derived from Yamoa (Funtumia elastica) prime gammadelta T cells in vitro and enhance innate immune responses in vivo.International immunopharmacology · 2009Article
- Neutralization of interleukin-10 from CD14(+) monocytes enhances gamma interferon production in peripheral blood mononuclear cells from Mycobacterium avium subsp. paratuberculosis-infected goats.Clinical and vaccine immunology : CVI · 2009Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have previously shown that CD8(+)gammadelta T cells decrease late allergic airway responses, airway eosinophilia, T helper 2 cytokine expression and increase interferon-gamma (IFN-gamma) expression. We hypothesized that the effects of CD8(+)gammadelta T cells were IFN-gamma mediated. Brown Norway rats were sensitized to ovalbumin on day 1. Cervical lymph node CD8(+)gammadelta T cells from sensitized animals were treated with antisense oligodeoxynucleotide (5 micromol/l) to inhibit IFN-gamma synthesis or control oligodeoxynucleotide and 3.5 x 10(4) CD8(+)gammadelta T cells were injected intraperitoneally into sensitized recipients on day 13. Rats were challenged with aerosolized ovalbumin on day 15 and lung resistance was monitored over an 8 hr period, after which bronchoalveolar lavage was performed. Control oligodeoxynucleotide treated gammadelta T cells decreased late airway responses and eosinophilia in bronchoalveolar lavage. There was a complete recovery of late airway responses and a partial recovery of airway eosinophilia in recipients of antisense oligodeoxynucleotide treated cells. Macrophage ingestion of eosinophils was frequent in rats administered gammadeltaT cells but reduced in recipients of antisense oligodeoxynucleotide treated cells. These results indicate that CD8(+)gammadelta T cells inhibit late airway responses and airway eosinophilia through the secretion of IFN-gamma. Defective or altered gammadelta T-cell function may account for some forms of allergic asthma.
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Registered trials
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