ArticleAmerican journal of human genetics2007
A chromosome 11q quantitative-trait locus influences change of blood-pressure measurements over time in Mexican Americans of the San Antonio Family Heart Study.
Article in American journal of human genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Five blood pressure loci identified by an updated genome-wide linkage scan: meta-analysis of the Family Blood Pressure Program.American journal of hypertension · 2011Pooled it
- An individualized Bayesian method for estimating genomic variants of hypertension.BMC genomics · 2023Article
- A PHLDB1 variant associated with the nonfunctional pituitary adenoma.Journal of neuro-oncology · 2019Article
- Rare variants in fox-1 homolog A (RBFOX1) are associated with lower blood pressure.PLoS genetics · 2017Article
- Comparison of 2 models for gene-environment interactions: an example of simulated gene-medication interactions on systolic blood pressure in family-based data.BMC proceedings · 2016Article
- Association between RTEL1, PHLDB1, and TREH Polymorphisms and Glioblastoma Risk: A Case-Control Study.Medical science monitor : international medical journal of experimental and clinical research · 2015Article
- BLID: A Novel Tumor-Suppressor Gene.Oncology research · 2014Review
- Plasma lipidomic profile signature of hypertension in Mexican American families: specific role of diacylglycerols.Hypertension (Dallas, Tex. : 1979) · 2013Article
- Between candidate genes and whole genomes: time for alternative approaches in blood pressure genetics.Current hypertension reports · 2012Review
- P-selectin Expression Tracks Cerebral Atrophy in Mexican-Americans.Frontiers in genetics · 2012Article
- Blood pressure and cerebral white matter share common genetic factors in Mexican Americans.Hypertension (Dallas, Tex. : 1979) · 2011Article
- Article
- Article
- Bivariate genetic association of KIAA1797 with heart rate in American Indians: the Strong Heart Family Study.Human molecular genetics · 2010Article
- Gene by smoking interaction in hypertension: identification of a major quantitative trait locus on chromosome 15q for systolic blood pressure in Mexican-Americans.Journal of hypertension · 2009Article
- Genetics of variation in serum uric acid and cardiovascular risk factors in Mexican Americans.The Journal of clinical endocrinology and metabolism · 2009Article
- Genetic effect on blood pressure is modulated by age: the Hypertension Genetic Epidemiology Network Study.Hypertension (Dallas, Tex. : 1979) · 2009Article
- Genetics of hypertension. Current status.Le Journal medical libanais. The Lebanese medical journalReview
- Genetic influences on serum bilirubin in American Indians: The Strong Heart Family Study.American journal of human biology : the official journal of the Human Biology CouncilArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 4 institutions in 2 countries.
Funding
Abstract
Although previous genome scans have searched for quantitative-trait loci (QTLs) influencing variation in blood pressure (BP), few have investigated the rate of change in BP over time as a phenotype. Here, we compare results from genomewide scans to localize QTLs for systolic, diastolic, and mean arterial BPs (SBP, DBP, and MBP, respectively) and for rates of change in systolic, diastolic, and mean arterial BPs (rSBP, rDBP, and rMBP, respectively), with use of the longitudinal data collected about Mexican Americans of the San Antonio Family Heart Study (SAFHS). Significant evidence of linkage was found for rSBP (LOD 4.15) and for rMBP (LOD 3.94) near marker D11S4464 located on chromosome 11q24.1. This same chromosome 11q region also shows suggestive linkage to SBP (LOD 2.23) and MBP (LOD 2.37) measurements collected during the second clinic visit. Suggestive evidence of linkage to chromosome 5 was also found for rMBP, to chromosome 16 for rSBP, and to chromosomes 1, 5, 6, 7, and 21 for the single-time-point BP traits collected at the first two SAFHS clinic visits. We also present results from fine mapping the chromosome 11 QTL with use of SNP-association analysis within candidate genes identified from a bioinformatic search of the region and from whole-genome transcriptional expression data collected from 1,240 SAFHS participants. Our results show that the use of longitudinal BP data to calculate the rate of change in BP over time provides more information than do the single-time measurements, since they reveal physiological trends in the subjects that a single-time measurement could never capture. Further investigation of this region is necessary for the identification of the genetic variation responsible for QTLs influencing the rate of change in BP.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.