ArticleCardiovascular engineering (Dordrecht, Netherlands)2007
Subject-specific model estimation of cardiac output and blood volume during hemorrhage.
Article in Cardiovascular engineering (Dordrecht, Netherlands), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Patient-specific multiscale modeling of blood flow for coronary artery bypass graft surgery.Annals of biomedical engineering · 2012Trial
- Effects of Pulsatile Flow on Fractional Flow Reserve Assessed Using a Reduced-Order Model.Annals of biomedical engineering · 2026Article
- A Novel Method for Cardiac Output and Vascular Parameters Estimation Using Peripheral Arterial Waveforms: Integrating Windkessel Model viaAnnals of biomedical engineering · 2026Article
- Computational modeling of heart failure in microgravity transitions.Frontiers in physiology · 2024Article
- Comparison of gastric reactance with commonly used perfusion markers in a swine hypovolemic shock model.Intensive care medicine experimental · 2022Article
- Patient-Specific Modelling and Parameter Optimisation to Simulate Dilated Cardiomyopathy in Children.Cardiovascular engineering and technology · 2022Article
- Predicting risk for trauma patients using static and dynamic information from the MIMIC III database.PloS one · 2022Article
- A computationally efficient physiologically comprehensive 3D-0D closed-loop model of the heart and circulation.Computer methods in applied mechanics and engineering · 2021Article
- Graph Representation Forecasting of Patient's Medical Conditions: Toward a Digital Twin.Frontiers in genetics · 2021Article
- Credibility Assessment of a Subject-Specific Mathematical Model of Blood Volume Kinetics for Prediction of Physiological Response to Hemorrhagic Shock and Fluid Resuscitation.Frontiers in physiology · 2021Article
- Optimization Framework for Patient-Specific Cardiac Modeling.Cardiovascular engineering and technology · 2019Article
- Coagulopathy implications using a multiscale model of traumatic bleeding matching macro- and microcirculation.American journal of physiology. Heart and circulatory physiology · 2019Article
- Multiscale systems biology of trauma-induced coagulopathy.Wiley interdisciplinary reviews. Systems biology and medicine · 2018Review
- The Pathway for Oxygen: Tutorial Modelling on Oxygen Transport from Air to Mitochondrion: The Pathway for Oxygen.Advances in experimental medicine and biology · 2016Article
- Left ventricular finite element model bounded by a systemic circulation model.Journal of biomechanical engineering · 2013Article
- JSim, an open-source modeling system for data analysis.F1000Research · 2013Article
- The Cardiac Physiome: perspectives for the future.Experimental physiology · 2009Review
- The Physiome Projects and Multiscale Modeling.IEEE signal processing magazine · 2008Article
- Coupling of a 3D finite element model of cardiac ventricular mechanics to lumped systems models of the systemic and pulmonic circulation.Annals of biomedical engineering · 2007Article
- Error detection and unit conversion.IEEE engineering in medicine and biology magazine : the quarterly magazine of the Engineering in Medicine & Biology SocietyArticle
Corrections and comments
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Authors and funding
2 authors.
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Abstract
We have developed a novel method for estimating subject-specific hemodynamics during hemorrhage. First, a mathematical model representing a closed-loop circulation and baroreceptor feedback system was parameterized to match the baseline physiology of individual experimental subjects by fitting model results to 1 min of pre-injury data. This automated parameterization process matched pre-injury measurements within 1.4 +/- 1.3% SD. Tuned parameters were then used in similar open-loop models to simulate dynamics post-injury. Cardiac output (CO) estimates were obtained continuously using post-injury measurements of arterial blood pressure (ABP) and heart rate (HR) as inputs to the first open-loop model. Secondarily, total blood volume (TBV) estimates were obtained by summing the blood volumes in all the circulatory segments of a second open-loop model that used measured CO as an additional input. We validated the estimation method by comparing model CO results to flowprobe measurements in 14 pigs. Overall, CO estimates had a Bland-Altman bias of -0.30 l/min with upper and lower limits of agreement 0.80 and -1.40 l/min. The negative bias is likely due to overestimation of the peripheral resistance response to hemorrhage. There was no reference measurement of TBV; however, the estimates appeared reasonable and clearly predicted survival versus death during the post-hemorrhage period. Both open-loop models ran in real time on a computer with a 2.4 GHz processor, and their clinical applicability in emergency care scenarios is discussed.
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Registered trials
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