Evidence map›Paper›PMID 17846875›Full record

ReviewMetabolic brain disease2007

The treatment of hepatic encephalopathy.

Marsha Y Morgan, A Blei, K Grüngreiff, R Jalan, G Kircheis, G Marchesini, O Riggio, Karin Weissenborn

Abstract readReview
PubMed Publisher
In one paragraph

Review in Metabolic brain disease, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.

  1. Probiotics for people with hepatic encephalopathy.The Cochrane database of systematic reviews · 2017
    Pooled it
  2. Trial
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Management of hepatic encephalopathy by traditional chinese medicine.Evidence-based complementary and alternative medicine : eCAM · 2012
    Article
  11. Article
  12. Article
  13. Review
  14. Hepatic encephalopathy therapy: An overview.World journal of gastrointestinal pharmacology and therapeutics · 2010
    Article
  15. Article
  16. Emerging Issues in Gastroenterology and Hepatology.Gastroenterology & hepatology · 2009
    Review
  17. Review
  18. Brain Edema in Chronic Hepatic Encephalopathy.Journal of clinical and experimental hepatology
    Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 8 institutions in 4 countries.

Marsha Y MorganCentre for Hepatology, Division of Medicine, Royal Free Campus, Royal Free and University College Medical School, University College London, London, UK. mymorgan@medsch.ucl.ac.uk
A Blei
K Grüngreiff
R Jalan
G Kircheis
G Marchesini
O Riggio
Karin Weissenborn
Heinrich Heine University Düsseldorf · DEMedizinische Hochschule Hannover · DENorthwestern University · USSapienza University of Rome · ITThe Royal Free Hospital · GBUniversity College London · GBUniversity Hospital Magdeburg · DEUniversity of Bologna · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current recommendations for the treatment of hepatic encephalopathy are based, to a large extent, on open or uncontrolled trials, undertaken in very small numbers of patients. In consequence, there is ongoing discussion as to whether the classical approach to the treatment of this condition, which aims at reducing ammonia production and absorption using either non-absorbable disaccharides and/or antibiotics, should be revisited, modified or even abandoned. Pros and cons of present therapeutic strategies and possible future developments were discussed at the fourth International Hannover Conference on Hepatic Encephalopathy held in Dresden in June 2006. The content of this discussion is summarized.

Indexed as

Amino Acids, Branched-ChainAnti-Bacterial AgentsDipeptidesHepatic EncephalopathyHumansLactuloseSugar AlcoholsZincAmino Acids, Branched-ChainAnti-Bacterial AgentsDipeptideslactitolLactuloseornithylaspartateSugar AlcoholsZinc

Identifiers

PMID17846875
OpenAlexW1990110631

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.