ArticleDevelopment genes and evolution2007
The gene doublesex of Anastrepha fruit flies (Diptera, Tephritidae) and its evolution in insects.
Article in Development genes and evolution, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Chromosome-scale genome assembly of the South American fruit fly, Anastrepha fraterculus sp.1.Insect science · 2026Article
- Next-generation genetic sexing strain establishment in the agricultural pest Ceratitis capitata.Scientific reports · 2023Article
- Transcriptome Analysis of the Oriental Fruit FlyInsects · 2020Article
- The study of the transformer gene from Bactrocera dorsalis and B. correcta with putative core promoter regions.BMC genetics · 2016Article
- Double nexus--Doublesex is the connecting element in sex determination.Briefings in functional genomics · 2015Review
- The ubiquity and ancestry of insect doublesex.Scientific reports · 2015Article
- Article
- Characterization of the doublesex gene within the Culex pipiens complex suggests regulatory plasticity at the base of the mosquito sex determination cascade.BMC evolutionary biology · 2015Article
- The evolutionary dynamics of major regulators for sexual development among Hymenoptera species.Frontiers in genetics · 2015Article
- Relevant genetic differentiation among Brazilian populations of Anastrepha fraterculus (Diptera, Tephritidae).ZooKeys · 2015Article
- Comprehensive transcriptome analysis of early male and female Bactrocera jarvisi embryos.BMC genetics · 2014Article
- Tribolium castaneum Transformer-2 regulates sex determination and development in both males and females.Insect biochemistry and molecular biology · 2013Article
- Article
- Doublesex target genes in the red flour beetle, Tribolium castaneum.Scientific reports · 2012Article
- Positive and purifying selection influence the evolution of doublesex in the Anastrepha fraterculus species group.PloS one · 2012Article
- Genomic organization and splicing evolution of the doublesex gene, a Drosophila regulator of sexual differentiation, in the dengue and yellow fever mosquito Aedes aegypti.BMC evolutionary biology · 2011Article
- Article
- Article
- Function and evolution of sex determination mechanisms, genes and pathways in insects.BioEssays : news and reviews in molecular, cellular and developmental biology · 2011Review
- Evidence for positive selection in the gene fruitless in Anastrepha fruit flies.BMC evolutionary biology · 2010Article
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6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The doublesex (dsx) gene of several Anastrepha species was isolated and characterised. Its molecular organisation was found to be the same in all the species examined. This gene is composed of four exons: Exons 1 and 2 are common to both sexes, exon 3 is female specific, and exon 4 is male specific. It codes for both the female DsxF and male DsxM proteins, corresponding to the sex-specific splicing product of its primary transcript; male-specific splicing is the default mode. A comparison of the Dsx proteins of different Anastrepha species with those of other insects showed them to be very similar. Molecular evolutionary analysis (both at the nucleotide and amino acid levels) of dsx in different insects revealed a topology in good agreement with their owners' taxonomic relationships. The great majority of the nucleotide changes detected in the dsx gene of the analysed species were significantly synonymous, evidence that strong purifying selection has acted on dsx so that the functional structure of the Dsx proteins is preserved. However, the common region of DsxF and DsxM proteins appeared to be the main target for selection acting upon the long-term evolution of gene dsx.
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