ArticleBone marrow transplantation2007
Six cases of permanent alopecia after various conditioning regimens commonly used in hematopoietic stem cell transplantation.
Article in Bone marrow transplantation, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 46 citations in OpenAlex.
- Chemotherapy-Induced Alopecia: Can We Measure the Level of Distress in Oncology Patients? (The ALDO Study).South Asian journal of cancer · 2023Article
- Dermatologic complications in transplantation and cellular therapy for acute leukemia.Best practice & research. Clinical haematology · 2023Review
- Permanent chemotherapy-induced alopecia after hematopoietic stem cell transplantation treated with low-dose oral minoxidil.JAAD case reports · 2022Article
- Permanent chemotherapy-induced alopecia: awareness and attitudes among health care providers.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020Article
- Priming mobilization of hair follicle stem cells triggers permanent loss of regeneration after alkylating chemotherapy.Nature communications · 2019Article
- Hair disorders in cancer survivors.Journal of the American Academy of Dermatology · 2019Review
- Permanent diffuse alopecia after haematopoietic stem cell transplantation in childhood.Bone marrow transplantation · 2017Article
- Supportive cryotherapy: a review from head to toe.Journal of pain and symptom management · 2014Review
- Clinical and histological study of permanent alopecia after bone marrow transplantation.Anais brasileiros de dermatologiaObservational
- Pediatric Ewing's Sarcoma and Permanent Chemotherapy-Induced Alopecia: A Case-Control Study.Pediatric dermatologyArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alopecia, a side effect of chemotherapy, is usually temporary and reversible. Irreversible alopecia has been reported after high-dose chemotherapy (HDC) and hematopoietic stem cell transplantation (HSCT) especially related to BuCy containing conditioning regimens; however, the overall incidence is not known. We conducted a retrospective study to identify patients with chemotherapy-induced permanent alopecia after HSCT. We describe six such patients, two males and four females, among 760 patients transplanted between 1997 and 2004. Median age was 45 years (range, 37-65). There were three Caucasians and three African-Americans. Median follow-up was 30 months. Conditioning regimens included BuCy, Bu/Cy and etoposide (VP16) (one of these patients received second autograft after Cy and TBI) and CyVP16 and TBI. Our data show that permanent alopecia is a significant long-term side effect of HSCT and can be seen across the spectrum of diseases and transplant types and with non-busulfan containing regimens. We have observed that patients usually accept permanent alopecia as the price for the cure and therefore true incidence of permanent alopecia may be underestimated. Our findings may also have medico legal and psychosocial implications that need to be taken into consideration when consenting patients for HSCT.
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