ArticleProceedings of the National Academy of Sciences of the United States of America2007
Targeting the absence: homozygous DNA deletions as immutable signposts for cancer therapy.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Tumors of the Nose and Paranasal Sinuses: Promoting Factors and Molecular Mechanisms-A Systematic Review.International journal of molecular sciences · 2023Pooled it
- Deletions of DNA in cancer and their possible uses for therapy.BioEssays : news and reviews in molecular, cellular and developmental biology · 2023Article
- Bringing Down Cancer Aircraft: Searching for Essential Hypomutated Proteins in Skin Melanoma.PloS one · 2015Article
- Targeting cancer's weaknesses (not its strengths): Therapeutic strategies suggested by the atavistic model.BioEssays : news and reviews in molecular, cellular and developmental biology · 2014Article
- 6-thioguanine: a drug with unrealized potential for cancer therapy.The oncologist · 2014Review
- Establishment and genetic characterization of six unique tumor cell lines as preclinical models for sinonasal squamous cell carcinoma.Scientific reports · 2014Article
- A systems approach defining constraints of the genome architecture on lineage selection and evolvability during somatic cancer evolution.Biology open · 2013Article
- Diversity in genetic in vivo methods for protein-protein interaction studies: from the yeast two-hybrid system to the mammalian split-luciferase system.Microbiology and molecular biology reviews : MMBR · 2012Review
- Turn-on DNA damage sensors for the direct detection of 8-oxoguanine and photoproducts in native DNA.Journal of the American Chemical Society · 2011Article
- Establishment and genetic characterization of an immortal tumor cell line derived from intestinal-type sinonasal adenocarcinoma.Cellular oncology (Dordrecht, Netherlands) · 2011Article
- A general approach for receptor and antibody-targeted detection of native proteins utilizing split-luciferase reassembly.ACS chemical biology · 2010Article
- Toward a general approach for RNA-templated hierarchical assembly of split-proteins.Journal of the American Chemical Society · 2010Article
- Cell cycle dependence of ionizing radiation-induced DNA deletions and antioxidant radioprotection in Saccharomyces cerevisiae.Radiation research · 2010Article
- Genetic and epigenetic inactivation of Kruppel-like factor 4 in medulloblastoma.Neoplasia (New York, N.Y.) · 2010Article
- Discovery of cellular regulation by protein degradation.The Journal of biological chemistry · 2008Article
- Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancers.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Core signaling pathways in human pancreatic cancers revealed by global genomic analyses.Science (New York, N.Y.) · 2008Article
- The simple and rapid detection of specific PCR products from bacterial genomes using Zn finger proteins.Nucleic acids research · 2008Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Many cancers harbor homozygous DNA deletions (HDs). In contrast to other attributes of cancer cells, their HDs are immutable features that cannot change during tumor progression or therapy. I describe an approach, termed deletion-specific targeting (DST), that employs HDs (not their effects on RNA/protein circuits, but deletions themselves) as the targets of cancer therapy. The DST strategy brings together both existing and new methodologies, including the ubiquitin fusion technique, the split-ubiquitin assay, zinc-finger DNA-recognizing proteins and split restriction nucleases. The DST strategy also employs a feedback mechanism that receives input from a circuit operating as a Boolean OR gate and involves the activation of split nucleases, which destroy DST vector in normal (nontarget) cells. The logic of DST makes possible an incremental and essentially unlimited increase in the selectivity of therapy. If DST strategy can be implemented in a clinical setting, it may prove to be curative and substantially free of side effects.
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