ArticleArchives of internal medicine2007
White matter lesions and the risk of incident hip fracture in older persons: results from the progetto veneto anziani study.
Article in Archives of internal medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Does atrial fibrillation increase the risk of fractures? A systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Association between pre-operative complications, comorbidities, and in-hospital mortality in a hip fracture cohort: a register study in a tertiary hospital in Brazil.International orthopaedics · 2022Article
- How does dementia interact with visit-to-visit blood pressure variability and hip fracture?Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019Article
- Article
- Incident atrial fibrillation and the risk of fracture in the cardiovascular health study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Article
- Ratio of urine albumin to creatinine attenuates the association of dementia with hip fracture risk.The Journal of clinical endocrinology and metabolism · 2014Article
- Elevated brain lesion volumes in older adults who use calcium supplements: a cross-sectional clinical observational study.The British journal of nutrition · 2014Observational
- Falls and Atrial Fibrillation in Elderly Patients.Acta Cardiologica Sinica · 2013Article
- Serum ionized calcium may be related to white matter lesion volumes in older adults: a pilot study.Nutrients · 2013Article
- Cardiovascular disease and hip fracture among older inpatients in Beijing, China.BioMed research international · 2013Article
- Metabolic syndrome and all-cause and cardiovascular mortality in an Italian elderly population: the Progetto Veneto Anziani (Pro.V.A.) Study.Diabetes care · 2009Article
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
Abstract
backgroundWhite matter lesions (WMLs) are associated with hypertension, an increased risk of falling, and impaired physical and cognitive performance that may affect the mechanical effect of falls.
methodsWe hypothesized that WMLs are a risk factor for hip fracture (HF). We studied a sample of 820 community-dwelling Italian persons 65 years and older from the cohort of the Progetto Veneto Anziani Study who underwent brain magnetic resonance imaging at baseline. Subjects were classified as having no lesions, focal lesions, or diffuse WMLs.
resultsCompared with those with no lesions, participants with diffuse WMLs were older, reported more falls, and had worse physical and cognitive performance, all factors implicated in the causal pathway to HF. During 9 years of follow-up, 51 HFs occurred. Hip fracture risk associated with diffuse WMLs markedly differed between participants younger than 80 years vs those 80 years and older. After adjustment among participants younger than 80 years, diffuse WMLs compared with no lesions were associated with a 2.7-fold (95% confidence interval, 1.1-7.1) increase in the risk of HF. Focal lesions were not statistically significantly associated with an increased risk of HF in the same age group (hazard ratio, 2.0; 95% confidence interval, 0.6-7.6). No associations between diffuse WMLs, focal lesions, and HF were evident among participants 80 years and older, possibly because of the limited sample size.
conclusionsWhite matter lesions represent an independent risk factor for HF in persons younger than 80 years. Older persons with diffuse WMLs should be considered candidates for multifactorial interventions aimed at reducing the risk of falling and fractures.
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