ArticleMetabolic brain disease2007
Caecal ligation and puncture in the rat mimics the pathophysiological changes in human sepsis and causes multi-organ dysfunction.
Article in Metabolic brain disease, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 68 citations in OpenAlex.
- Extracellular Histones Associate with Blood-Brain Barrier Disruption and Astrocyte-Mediated Neuroinflammation During Polymicrobial Sepsis.International journal of molecular sciences · 2026Article
- A neutrophil elastase inhibitor, sivelestat, attenuates sepsis-induced acute kidney injury by inhibiting oxidative stress.Heliyon · 2024Article
- Morphine aggravates inflammatory, behavioral, and hippocampal structural deficits in septic rats.Scientific reports · 2023Article
- Adapted Murine Sepsis Score: Improving the Research in Experimental Sepsis Mouse Model.BioMed research international · 2022Article
- Correlation of Impaired NF-Journal of healthcare engineering · 2021Article
- Circular RNA VMA21 ameliorates sepsis-associated acute kidney injury by regulating miR-9-3p/SMG1/inflammation axis and oxidative stress.Journal of cellular and molecular medicine · 2020Article
- Immunomodulatory dose of clindamycin in combination with ceftriaxone improves survival and prevents organ damage in murine polymicrobial sepsis.Naunyn-Schmiedeberg's archives of pharmacology · 2020Article
- Anastomotic healing in a rat model of peritonitis after non-steroidal anti-inflammatory drug administration.European journal of histochemistry : EJH · 2020Article
- Data on changes of NF-κB gene expression in liver and lungs as a biomarker and hepatic injury in CLP-induced septic rats.Data in brief · 2019Article
- Cannabinoid CBInflammation · 2019Article
- Whey Acidic Protein/Four-Disulfide Core Domain 21 Regulate Sepsis Pathogenesis in a Mouse Model and a Macrophage Cell Line via the Stat3/Toll-Like Receptor 4 (TLR4) Signaling Pathway.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Granulocyte and monocyte adsorptive apheresis ameliorates sepsis in rats.Intensive care medicine experimental · 2017Article
- Metformin ameliorates sepsis-induced brain injury by inhibiting apoptosis, oxidative stress and neuroinflammation via the PI3K/Akt signaling pathway.Oncotarget · 2017Article
- The lipoxin ANaunyn-Schmiedeberg's archives of pharmacology · 2017Article
- The Natural History of Pneumonic Tularemia in Female Fischer 344 Rats after Inhalational Exposure to Aerosolized Francisella tularensis Subspecies tularensis Strain SCHU S4.The American journal of pathology · 2017Article
- Treatment with 24 h-delayed normo- and hyperbaric oxygenation in severe sepsis induced by cecal ligation and puncture in rats.Journal of inflammation (London, England) · 2017Article
- Endothelial bioreactor system ameliorates multiple organ dysfunction in septic rats.Intensive care medicine experimental · 2016Article
- The neutrophil elastase inhibitor, sivelestat, attenuates sepsis-related kidney injury in rats.International journal of molecular medicine · 2016Article
- The Severity of Cecal Ligature and Puncture-Induced Sepsis Correlates with the Degree of Encephalopathy, but the Sepsis Does Not Lead to Acute Activation of Spleen Lymphocytes in Mice.Molecular neurobiology · 2016Article
- New Insights into Sepsis Therapy Using Sepia Officinalis.Jundishapur journal of microbiology · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sepsis is a major clinical challenge that is associated with encephalopathy and multi-organ dysfunction. Current therapeutic interventions are relatively ineffective and the development of novel treatments is hampered by the lack of a well-characterised animal model. Therefore, the behavioural, metabolic, physiological and histological changes resulting from 'through and through' caecal ligation and puncture (CLP) in the rat were investigated to determine its suitability as an animal model of human sepsis. CLP resulted in bacteraemia, characterised by the presence of multiple enteric species within 18-20 h. Locomotor activity was reduced within 4 h of CLP and this reduction increased with time. Pyrexia was evident 4-5 h after CLP and was followed by hypothermia beginning 17 h after intervention. CLP resulted in reduced white blood cell and platelet counts and an increased neutrophil: lymphocyte ratio within 18-20 h. It also resulted in decreased blood glucose, but not lactate levels. CLP caused histopathological changes in the cerebral cortex, liver, lungs and vascular system indicative of multi-organ dysfunction. Therefore, CLP in the rat mimics the cardinal clinical features of human sepsis and the subsequent development of multi-organ dysfunction. It appears to be the best available animal model currently available, in which to investigate the underlying pathophysiology of sepsis and identify therapeutic targets.
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