Evidence map›Paper›PMID 17828470›Full record

ReviewCancer metastasis reviews2007

Chemokines in tumor angiogenesis and metastasis.

Seema Singh, Anguraj Sadanandam, Rakesh K Singh

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancer metastasis reviews, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
98citing papers in PubMed, 1 pooled it
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

98 citing papers in PubMed, 1 synthesis or guideline pooled it, 166 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. Review

38 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Seema SinghDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198-5845, USA.
Anguraj Sadanandam
Rakesh K Singh
University of Nebraska Medical Center · US

Funding

Molecular Regulation of Human Melanoma MetastasisR01CA072781 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI SINGH, RAKESH K · 2005 to 2007
$580k
MOLECULAR REGULATION OF HUMAN MELANOMA METASTASISR29CA072781 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI SINGH, RAKESH K · 1998 to 2002
$308k
NCI NIH HHS CA72781NCI NIH HHS R01 CA072781NCI NIH HHS R29 CA072781
6 · The paper itself

Abstract

Chemokines are a large group of low molecular weight cytokines that are known to selectively attract and activate different cell types. Although the primary function of chemokines is well recognized as leukocyte attractants, recent evidences indicate that they also play a role in number of tumor-related processes, such as growth, angiogenesis and metastasis. Chemokines activate cells through cell surface seven trans-membranes, G-protein-coupled receptors (GPCR). The role played by chemokines and their receptors in tumor pathophysiology is complex as some chemokines favor tumor growth and metastasis, while others may enhance anti-tumor immunity. These diverse functions of chemokines establish them as key mediators between the tumor cells and their microenvironment and play critical role in tumor progression and metastasis. In this review, we present some of the recent advances in chemokine research with special emphasis on its role in tumor angiogenesis and metastasis.

Indexed as

Neoplasm MetastasisAnimalsChemokinesHumansNeoplasmsNeovascularization, PathologicReceptors, ChemokineSignal TransductionChemokinesReceptors, Chemokine

Identifiers

PMID17828470
PMCPMC4237067
OpenAlexW2070338369

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.