ArticleAnnals of surgical oncology2007
Intrahepatic lymphatic invasion independently predicts poor survival and recurrences after hepatectomy in patients with colorectal carcinoma liver metastases.
Article in Annals of surgical oncology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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21 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Histopathological prognostic factors for colorectal liver metastases: A systematic review and meta-analysis of observational studies.Histology and histopathology · 2021Pooled it
- Randomized Phase III Study to Assess Efficacy and Safety of Adjuvant CAPOX with or without Bevacizumab in Patients after Resection of Colorectal Liver Metastases: HEPATICA study.Neoplasia (New York, N.Y.) · 2017Trial
- Prognostic impact of intrahepatic lymphatic and microvascular involvement in cases of colorectal liver metastases.International journal of colorectal disease · 2009Trial
- Utilizing imaging features of preoperative gadoxetic acid-enhanced MRI for predicting lymphovascular invasion in colorectal cancer liver metastases and exploring its impact on survival.BMC medical imaging · 2026Article
- Effect of Lymphatic Invasion on Survival and Recurrence After Liver Transplantation in Patients with Hepatocellular Carcinoma and Its Prognostic Significance.Diagnostics (Basel, Switzerland) · 2026Article
- VEGF-C propagates 'onward' colorectal cancer metastasis from liver to lung.British journal of cancer · 2025Article
- Review
- Article
- Simultaneous curative resection of double colorectal carcinoma with synchronous bilobar liver metastases.World journal of gastrointestinal oncology · 2018Review
- Laparoscopic Parenchyma-sparing Liver Resection for Colorectal Metastases.Radiology and oncology · 2018Article
- Parenchymal-sparing liver surgery in patients with colorectal carcinoma liver metastases.World journal of gastrointestinal surgery · 2016Review
- The Role of Lymphatic Endothelial Cells in Liver Injury and Tumor Development.Frontiers in immunology · 2016Review
- Lymphatic Invasion is an Independent Adverse Prognostic Factor in Patients with Colorectal Liver Metastasis.Annals of surgical oncology · 2015Article
- Safety analysis of the oncological outcome after vein-preserving surgery for colorectal liver metastases detached from the main hepatic veins.Langenbeck's archives of surgery · 2015Article
- Lymphatic drainage of the liver and its implications in the management of colorectal cancer liver metastases.Updates in surgery · 2014Review
- Critical review of the prognostic significance of pathological variables in patients undergoing resection for colorectal liver metastases.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2014Article
- Intrahepatic lymphatic invasion but not vascular invasion is a major prognostic factor after resection of colorectal cancer liver metastases.World journal of surgery · 2014Article
- Management of colorectal cancer patients after resection of liver metastases: can we offer a tailored treatment?Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2012Article
- Survival after liver resection in metastatic colorectal cancer: review and meta-analysis of prognostic factors.Clinical epidemiology · 2012Article
- Histologic evaluation of intrahepatic micrometastases in patients treated with or without neoadjuvant chemotherapy for colorectal carcinoma liver metastasis.International journal of clinical and experimental pathology · 2012Article
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8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundD2-40 monoclonal antibody immunoreactivity is specific for lymphatic endothelium and therefore provides a marker of lymphatic invasion. We hypothesized that intrahepatic lymphatic invasion reflects the nodal status of colorectal carcinoma liver metastases and may function as an adverse prognostic factor.
methodsA retrospective analysis of 105 consecutive patients who underwent resection for colorectal carcinoma liver metastases was conducted. Intrahepatic lymphatic invasion was declared when either single tumor cells or cell clusters were clearly visible within vessels that showed immunoreactivity for D2-40 monoclonal antibody. The median follow-up time was 124 months.
resultsOf 105 patients, 13 were classified as having intrahepatic lymphatic invasion. All tumor foci of intrahepatic lymphatic invasion were detected within the portal tracts. Intrahepatic lymphatic invasion was significantly associated with hepatic lymph node involvement (P = 0.039). Survival after resection was significantly worse in patients with intrahepatic lymphatic invasion (median survival time of 13 months; cumulative five-year survival rate of 0%) than in patients without (median survival time of 40 months; cumulative five-year survival rate of 41%; P < 0.0001). Patients with intrahepatic lymphatic invasion also showed decreased disease-free survival rates (P < 0.0001). Intrahepatic lymphatic invasion thus independently affected both survival (relative risk, 7.666; 95% confidence interval, 3.732-15.748; P < 0.001) and disease-free survival (relative risk, 4.112; 95% confidence interval, 2.185-7.738; P < 0.001).
conclusionsIntrahepatic lymphatic invasion is associated with hepatic lymph node involvement and is an adverse prognostic factor in patients with colorectal carcinoma liver metastases.
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