ArticleMolecular and cellular biochemistry2008
Interaction between importin 13 and myopodin suggests a nuclear import pathway for myopodin.
Article in Molecular and cellular biochemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Synaptopodin-2: a potential tumor suppressor.Cancer cell international · 2023Review
- Importin 13 promotes NSCLC progression by mediating RFPL3 nuclear translocation and hTERT expression upregulation.Cell death & disease · 2020Article
- Copy number variants in Ebstein anomaly.PloS one · 2017Article
- Myopodin methylation is a prognostic biomarker and predicts antiangiogenic response in advanced kidney cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Expression and subcellular distribution of imp13 are regulated in brain development.In vitro cellular & developmental biology. Animal · 2013Article
- CCCTC-binding factor controls its own nuclear transport via regulating the expression of importin 13.Molecules and cells · 2013Article
- Structural basis for the nuclear export activity of Importin13.The EMBO journal · 2013Article
- Increased expression of importin13 in endometriosis and endometrial carcinoma.Medical science monitor : international medical journal of experimental and clinical research · 2012Article
- Diagnostic and prognostic utility of methylation and protein expression patterns of myopodin in colon cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2012Article
- Nuclear import by karyopherin-βs: recognition and inhibition.Biochimica et biophysica acta · 2011Review
- Expression of the nuclear transport protein importin ß-1 and its association with the neurokinin 3 receptor in the rat hypothalamus following acute hyperosmotic challenge.Neuroscience · 2010Article
- Importin 13 serves as a potential marker for corneal epithelial progenitor cells.Stem cells (Dayton, Ohio) · 2009Article
- The roles of multiple importins for nuclear import of murine aristaless-related homeobox protein.The Journal of biological chemistry · 2009Article
- Importin 13 regulates neurotransmitter release at the Drosophila neuromuscular junction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Importin 13 mediates nuclear import of histone fold-containing chromatin accessibility complex heterodimers.The Journal of biological chemistry · 2009Article
- Regulation of nuclear import and export of negative cofactor 2.The Journal of biological chemistry · 2009Article
- Importins and exportins in cellular differentiation.Journal of cellular and molecular medicine · 2008Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Importin 13 is a member of the importin beta superfamily of nuclear transport proteins and is expressed in multiple tissues at high levels both in humans and rodents, including fetal lung, brain, and heart. In order to elucidate potential functions of imp13 in the heart, we have used rat imp13 as bait to screen a human heart cDNA library and identified an interaction with the C-terminal peptide of myopodin (a.a. 360-698), an actin-bundling protein, associated with tumor-suppressor activity that localizes to both the cytoplasm and the nucleus. We have used GST-pull down assays and co-immunoprecipitation experiments to demonstrate an interaction between imp13 and full-length myopodin and observed that RanGTP dissociates the myopodin-imp13 complex. In studies of cultured cells, we show that both imp13 siRNA and a C-terminal fragment of imp13 protein prevent nuclear localization of myopodin. We, therefore, conclude that imp13 functions in myopodin import and we suggest that the regulation of these events is critical for normal and abnormal cellular differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.