ArticleThe Plant cell2007
AP2-ERF transcription factors mediate Nod factor dependent Mt ENOD11 activation in root hairs via a novel cis-regulatory motif.
Article in The Plant cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers.
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99 citing papers in PubMed, 221 citations in OpenAlex.
- Transcriptomic Analysis Reveals the Role ofPlants (Basel, Switzerland) · 2026Article
- Hormone-modulated transcription factors orchestrating the root nodule symbiosis.Frontiers in plant science · 2026Review
- Genome-wide analysis of the AP2/ERF transcription factor superfamily in perennial ryegrass.BMC genomics · 2025Article
- Genetic dissection of maize grain moisture content and dehydration rate using high-density bin mapping in a recombinant inbred line population.BMC plant biology · 2025Article
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- Mapping the molecular landscape of Lotus japonicus nodule organogenesis through spatiotemporal transcriptomics.Nature communications · 2024Article
- A spatially resolved multiomic single-cell atlas of soybean development.bioRxiv : the preprint server for biology · 2024Article
- Biophysical and proteomic analyses ofmBio · 2023Article
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- The developmental dynamics in cool season legumes with focus on chickpea.Plant molecular biology · 2023Review
- Roles of a CCR4-NOT complex component GmNOT4-1 in regulating soybean nodulation.Frontiers in plant science · 2023Article
- Genome-Wide Identification ofInternational journal of molecular sciences · 2022Article
- Deciphering the role of SPL12 and AGL6 from a genetic module that functions in nodulation and root regeneration in Medicago sativa.Plant molecular biology · 2022Article
- A mutant-based analysis of the establishment of Nod-independent symbiosis in the legume Aeschynomene evenia.Plant physiology · 2022Article
- MtEFD and MtEFD2: Two transcription factors with distinct neofunctionalization in symbiotic nodule development.Plant physiology · 2022Article
- Progress in the Self-Regulation System in Legume Nodule Development-AON (Autoregulation of Nodulation).International journal of molecular sciences · 2022Review
- The effects of ERN1 on gene expression during early rhizobial infection inFrontiers in plant science · 2022Article
- Regulation of the Later Stages of Nodulation Stimulated by IPD3/CYCLOPS Transcription Factor and Cytokinin in PeaPlants (Basel, Switzerland) · 2021Article
- Salt Stress Enhances Early Symbiotic Gene Expression inMolecular plant-microbe interactions : MPMI · 2021Article
39 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rhizobium Nod factors (NFs) are specific lipochitooligosaccharides that activate host legume signaling pathways essential for initiating the nitrogen-fixing symbiotic association. This study describes the characterization of cis-regulatory elements and trans-interacting factors that regulate NF-dependent and epidermis-specific gene transcription in Medicago truncatula. Detailed analysis of the Mt ENOD11 promoter using deletion, mutation, and gain-of-function constructs has led to the identification of an NF-responsive regulatory unit (the NF box) sufficient to direct NF-elicited expression in root hairs. NF box-mediated expression requires a major GCC-like motif, which is also essential for the binding of root hair-specific nuclear factors. Yeast one-hybrid screening has identified three closely related AP2/ERF transcription factors (ERN1 to ERN3) that are able to bind specifically to the NF box. ERN1 is identical to an ERF-like factor identified recently. Expression analysis has revealed that ERN1 and ERN2 genes are upregulated in root hairs following NF treatment and that this activation requires a functional NFP gene. Transient expression assays in Nicotiana benthamiana have further shown that nucleus-targeted ERN1 and ERN2 factors activate NF box-containing reporters, whereas ERN3 represses ERN1/ERN2-dependent transcription activation. A model is proposed for the fine-tuning of NF-elicited gene transcription in root hairs involving the interplay between repressor and activator ERN factors.
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