ArticleApplied and environmental microbiology2007
Impact of feed supplementation with antimicrobial agents on growth performance of broiler chickens, Clostridium perfringens and enterococcus counts, and antibiotic resistance phenotypes and distribution of antimicrobial resistance determinants in Escherichia coli isolates.
Article in Applied and environmental microbiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
59 citing papers in PubMed, 199 citations in OpenAlex.
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- Analysis of Multi-Antimicrobial Resistance Patterns in U.S. Foodborne Pathogens (2015-2025) Using Data from the NCBI Pathogen Isolates Browser.Pathogens (Basel, Switzerland) · 2025Article
- Review
- Comprehensive analysis of antimicrobial resistance dynamics among broiler and duck intensive production systems.Scientific reports · 2025Article
- Risk of Colonization with Multidrug-Resistant Gram-Negative Bacteria Among Travellers and Migrants: A Narrative Review.Tropical medicine and infectious disease · 2025Review
- Antibiotic profiling of multidrug resistant pathogens in one-day-old chicks imported from Belgium to benin.BMC veterinary research · 2023Article
- Effects of paraprobiotic as replacements for antibiotic on performance, immunity, gut health and carcass characteristics in broiler chickens.Scientific reports · 2022Article
- Production systems and important antimicrobial resistant-pathogenic bacteria in poultry: a review.Journal of animal science and biotechnology · 2022Review
- Amoxicillin and thiamphenicol treatments may influence the co-selection of resistance genes in the chicken gut microbiota.Scientific reports · 2022Article
- Oral Administration of a Phage Cocktail to ReduceAnimals : an open access journal from MDPI · 2022Article
- Metagenomic assembly reveals hosts and mobility of common antibiotic resistome in animal manure and commercial compost.Environmental microbiome · 2022Article
- Riboflavin andJournal of animal science and technology · 2022Article
- Effects of Postbiotics and Paraprobiotics as Replacements for Antibiotics on Growth Performance, Carcass Characteristics, Small Intestine Histomorphology, Immune Status and Hepatic Growth Gene Expression in Broiler Chickens.Animals : an open access journal from MDPI · 2022Article
- Village-Indigenous Chicken Bacterial Carriage after the Heavy Rains of 2018, Kenya: Indicator on Environmental Contamination with Pathogenic/Zoonotic Bacteria.Veterinary medicine international · 2022Article
- Genomic Characterization of TwoFrontiers in cellular and infection microbiology · 2022Article
- Rethinking Manure Application: Increase in Multidrug-ResistantMicroorganisms · 2021Article
- Effects of hulless barley and exogenous beta-glucanase levels on ileal digesta soluble beta-glucan molecular weight, digestive tract characteristics, and performance of broiler chickens.Poultry science · 2021Article
- Poultry and Wild Birds as a Reservoir of CMY-2 ProducingAntibiotics (Basel, Switzerland) · 2021Article
- Characterization ofIranian journal of veterinary research · 2021Article
- Molecular Epidemiology of Antibiotic-ResistantAntibiotics (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effects of feed supplementation with the approved antimicrobial agents bambermycin, penicillin, salinomycin, and bacitracin or a combination of salinomycin plus bacitracin were evaluated for the incidence and distribution of antibiotic resistance in 197 commensal Escherichia coli isolates from broiler chickens over 35 days. All isolates showed some degree of multiple antibiotic resistance. Resistance to tetracycline (68.5%), amoxicillin (61.4%), ceftiofur (51.3%), spectinomycin (47.2%), and sulfonamides (42%) was most frequent. The levels of resistance to streptomycin, chloramphenicol, and gentamicin were 33.5, 35.5, and 25.3%, respectively. The overall resistance levels decreased from day 7 to day 35 (P < 0.001). Comparing treatments, the levels of resistance to ceftiofur, spectinomycin, and gentamicin (except for resistance to bacitracin treatment) were significantly higher in isolates from chickens receiving feed supplemented with salinomycin than from the other feeds (P < 0.001). Using a DNA microarray analysis capable of detecting commonly found antimicrobial resistance genes, we characterized 104 tetracycline-resistant E. coli isolates from 7- to 28-day-old chickens fed different growth promoters. Results showed a decrease in the incidence of isolates harboring tet(B), bla(TEM), sulI, and aadA and class 1 integron from days 7 to 35 (P < 0.01). Of the 84 tetracycline-ceftiofur-resistant E. coli isolates, 76 (90.5%) were positive for bla(CMY-2). The proportions of isolates positive for sulI, aadA, and integron class 1 were significantly higher in salinomycin-treated chickens than in the control or other treatment groups (P < 0.05). These data demonstrate that multiantibiotic-resistant E. coli isolates can be found in broiler chickens regardless of the antimicrobial growth promoters used. However, the phenotype and the distribution of resistance determinants in E. coli can be modulated by feed supplementation with some of the antimicrobial agents used in broiler chicken production.
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