ArticleJournal of bacteriology2007
The alanine racemase of Mycobacterium smegmatis is essential for growth in the absence of D-alanine.
Article in Journal of bacteriology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed, 50 citations in OpenAlex.
- Article
- Transient infection ofApplied and environmental microbiology · 2024Article
- Article
- Increased levels of oral Streptococcus-derived D-alanine in patients with chronic kidney disease and diabetes mellitus.Scientific reports · 2022Article
- Synthesis, Biological Evaluation and Computational Studies of New Hydrazide Derivatives Containing 1,3,4-Oxadiazole as Antitubercular Agents.International journal of molecular sciences · 2022Article
- Cell wall peptidoglycan in Mycobacterium tuberculosis: An Achilles' heel for the TB-causing pathogen.FEMS microbiology reviews · 2019Review
- Identification of a new alanine racemase inGut pathogens · 2018Article
- Peptide Ligands of AmiA, AliA, and AliB Proteins Determine Pneumococcal Phenotype.Frontiers in microbiology · 2018Article
- Auxotrophy to Xeno-DNA: an exploration of combinatorial mechanisms for a high-fidelity biosafety system for synthetic biology applications.Journal of biological engineering · 2018Review
- Role of Alanine Racemase Mutations in Mycobacterium tuberculosis d-Cycloserine Resistance.Antimicrobial agents and chemotherapy · 2017Article
- Assessment of Metabolic Changes in Mycobacterium smegmatis Wild-Type and alr Mutant Strains: Evidence of a New Pathway of d-Alanine Biosynthesis.Journal of proteome research · 2017Article
- Benzoic Acid-Inducible Gene Expression in Mycobacteria.PloS one · 2015Article
- Article
- Investigation of the essentiality of glutamate racemase in Mycobacterium smegmatis.Journal of bacteriology · 2014Article
- Identifying feasible metabolic routes in Mycobacterium smegmatis and possible alterations under diverse nutrient conditions.BMC microbiology · 2014Article
- Metabolomics analysis identifies d-Alanine-d-Alanine ligase as the primary lethal target of d-Cycloserine in mycobacteria.Journal of proteome research · 2014Article
- Inhibition of mycobacterial alanine racemase activity and growth by thiadiazolidinones.Biochemical pharmacology · 2013Article
- The crystal structure of alanine racemase from Streptococcus pneumoniae, a target for structure-based drug design.BMC microbiology · 2011Article
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- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alanine racemase, encoded by the gene alr, is an important enzyme in the synthesis of d-alanine for peptidoglycan biosynthesis. Strains of Mycobacterium smegmatis with a deletion mutation of the alr gene were found to require d-alanine for growth in both rich and minimal media. This indicates that alanine racemase is the only source of d-alanine for cell wall biosynthesis in M. smegmatis and confirms alanine racemase as a viable target gene for antimycobacterial drug development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.