ArticlePlant physiology2007
Rice P1B-type heavy-metal ATPase, OsHMA9, is a metal efflux protein.
Article in Plant physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.
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Who cites it
82 citing papers in PubMed, 275 citations in OpenAlex.
- Article
- Molecular insights into cadmium transport and micronutrient crosstalk in rice: Towards minimizing grain Cd.Journal of integrative plant biology · 2026Review
- Co-application of biochar and melatonin enhances rice resilience to combined lead and microplastics stress via modulating antioxidant defense, hormonal regulation, gene expression, and soil quality.BMC plant biology · 2026Article
- Assessing lead toxicity induced alterations in expression of transmembrane metal transporter OsHMA9 and physio-biochemical activities of canola.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Article
- Molecular Evolution of Cu Transporters and Transcription Factors in Plant Response to Copper Stress.Plants (Basel, Switzerland) · 2025Review
- A Review of Reducing Cadmium Pollution in the Rice-Soil System in China.Foods (Basel, Switzerland) · 2025Review
- QTL mapping and candidate gene analysis of element accumulation in rice grains via genome-wide association study and population genetic analysis.BMC plant biology · 2025Article
- Integrative biochar and melatonin application mitigates lead toxicity in rice by modulating antioxidant activities and iron plaque formation and downregulating the expression of metal uptake genes.Frontiers in plant science · 2025Article
- Copper connections: coordinating transport, sensing and systemic signalling in plants.Quantitative plant biology · 2025Review
- Effect of pH on growth and Cd accumulation in different rice varieties under hydroponics.Plant signaling & behavior · 2024Article
- Multiomics and biotechnologies for understanding and influencing cadmium accumulation and stress response in plants.Plant biotechnology journal · 2024Review
- Molecular Mechanisms of Plant Responses to Copper: From Deficiency to Excess.International journal of molecular sciences · 2024Review
- Genome-wide identification of heavy-metal ATPases genes in Areca catechu: investigating their functionality under heavy metal exposure.BMC plant biology · 2024Article
- The Uptake, Transfer, and Detoxification of Cadmium in Plants and Its Exogenous Effects.Cells · 2024Review
- Decrypting Molecular Mechanisms Involved in Counteracting Copper and Nickel Toxicity in Jack Pine (Plants (Basel, Switzerland) · 2024Article
- Silicon and iron nanoparticles protect rice against lead (Pb) stress by improving oxidative tolerance and minimizing Pb uptake.Scientific reports · 2024Article
- Genome-Wide Identification and Expression Profiling of Heavy Metal ATPase (HMA) Genes in Peanut: Potential Roles in Heavy Metal Transport.International journal of molecular sciences · 2024Article
- Article
- Adenosine-Monophosphate-Assisted Homogeneous Silica Coating of Silver Nanoparticles in High Yield.Nanomaterials (Basel, Switzerland) · 2023Article
- Inhibition Roles of Calcium in Cadmium Uptake and Translocation in Rice: A Review.International journal of molecular sciences · 2023Review
22 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
P(1B)-type heavy-metal ATPases (HMAs) are transmembrane metal-transporting proteins that play a key role in metal homeostasis. Despite their importance, very little is known about their functions in monocot species. We report the characterization of rice (Oryza sativa) OsHMA9, a member of the P(1B)-type ATPase family. Semiquantitative reverse transcription-polymerase chain reaction analyses of seedlings showed that OsHMA9 expression was induced by a high concentration of copper (Cu), zinc (Zn), and cadmium. We also determined, through promoterbeta-glucuronidase analysis, that the main expression was in the vascular bundles and anthers. The OsHMA9:green fluorescence protein fusion was localized to the plasma membrane. Heterologous expression of OsHMA9 partially rescued the Cu sensitivity of the Escherichia coli copA mutant, which is defective in Cu-transporting ATPases. It did not rescue the Zn sensitivity of the zntA mutant, which is defective in Zn-transporting ATPase. To further elucidate the functional roles of OsHMA9, we isolated two independent null alleles, oshma9-1 and oshma9-2, from the T-DNA insertion population. Mutant plants exhibited the phenotype of increased sensitivity to elevated levels of Cu, Zn, and lead. These results support a role for OsHMA9 in Cu, Zn, and lead efflux from the cells. This article is the first report on the functional characterization of a P(1B)-type metal efflux transporter in monocots.
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