ArticleBiophysical journal2008
Buffered diffusion around a spherical proton pumping cell: a theoretical analysis.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Fluorescent Visualization of Cellular Proton Fluxes.Cell chemical biology · 2016Article
- Protons Trigger Mitochondrial Flashes.Biophysical journal · 2016Article
- Temperature dependence of proton permeation through a voltage-gated proton channel.The Journal of general physiology · 2009Article
- Residues important for nitrate/proton coupling in plant and mammalian CLC transporters.The Journal of biological chemistry · 2009Article
- Conversion of the 2 Cl(-)/1 H+ antiporter ClC-5 in a NO3(-)/H+ antiporter by a single point mutation.The EMBO journal · 2009Article
- Voltage-gated proton channels: what's next?The Journal of physiology · 2008Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
H(+) ions are a substrate of many active and passive membrane transporters in all cells. Absolute proton fluxes are often quantified using intracellular pH sensitive microelectrodes or pH sensitive dyes. These measurements, however, rely on a priori estimates of the intracellular buffer capacity and on the assumption of diffusive equilibrium inside the cell. Here, assuming local equilibrium of protons with a single mobile buffer, we model the diffusion of H(+) in the extracellular medium around an H(+) pumping cell to estimate the expected pH changes as a function of time, distance from the cell, extracellular buffer capacity, and the absolute proton flux across the membrane. In particular, using accurate numerical simulation, we gauge the range of validity of an explicit, analytical solution of the linearized, nonstationary diffusion equation. Our results provide a framework to quantify the absolute membrane proton flux, if spatiotemporal information about the extracellular pH change is available, e.g., using imaging of pH dependent fluorescent dyes.
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Registered trials
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