ArticleHormones and behavior2007
Corticotropin releasing factor induces anxiogenic locomotion in trout and alters serotonergic and dopaminergic activity.
Article in Hormones and behavior, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 73 citations in OpenAlex.
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- Crhr1 and epinephrine utilize the central Ras-MAPK pathway in mediating the acute stress-related locomotor activity in zebrafish larvae.Frontiers in endocrinology · 2025Article
- Chronic social isolation affects feeding behavior of juvenile zebrafish (Danio rerio).PloS one · 2024Article
- Subpopulations of hypocretin/orexin neurons differ in measures of their cell proliferation, dynorphin co-expression, projections, and response to embryonic ethanol exposure.Scientific reports · 2023Article
- Article
- Anxiolytic reversal of classically conditioned / chronic stress-induced gene expression and learning in the Stress Alternatives Model.Behavioural brain research · 2023Article
- Melatonin as an anti-stress signal: effects on an acute stress model and direct actions on interrenal tissue in goldfish.Frontiers in endocrinology · 2023Article
- Social effects on AVT and CRF systems.Fish physiology and biochemistry · 2021Article
- Parental selection for growth and early-life low stocking density increase the female-to-male ratio in European sea bass.Scientific reports · 2021Article
- Polystyrene nanoplastics disrupt glucose metabolism and cortisol levels with a possible link to behavioural changes in larval zebrafish.Communications biology · 2019Article
- Persistent Effects of Developmental Exposure to 17α-Ethinylestradiol on the Zebrafish (Frontiers in behavioral neuroscience · 2017Article
- Learning and CRF-Induced Indecision during Escape and Submission in Rainbow Trout during Socially Aggressive Interactions in the Stress-Alternatives Model.Frontiers in neuroscience · 2017Article
- Serotonin Coordinates Responses to Social Stress-What We Can Learn from Fish.Frontiers in neuroscience · 2017Review
- Article
- An affective disorder in zebrafish with mutation of the glucocorticoid receptor.Molecular psychiatry · 2013Article
- Regulation of feeding behavior and psychomotor activity by corticotropin-releasing hormone (CRH) in fish.Frontiers in neuroscience · 2013Article
- Central corticotropin releasing factor and social stress.Frontiers in neuroscience · 2013Article
- Appetite-suppressing effects and interactions of centrally administered corticotropin-releasing factor, urotensin I and serotonin in rainbow trout (Oncorhynchus mykiss).Frontiers in neuroscience · 2013Article
- Brainstem neuronal and behavioral activation by corticotropin-releasing hormone depend on the behavioral state of the animal.Hormones and behavior · 2012Article
- Brainstem reticulospinal neurons are targets for corticotropin-releasing factor-Induced locomotion in roughskin newts.Hormones and behavior · 2010Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Corticotropin releasing factor (CRF) and serotonin (5-HT) are strongly linked to stress and anxiety in vertebrates. As a neuromodulator in the brain, CRF has anxiogenic properties often characterized by increased locomotion and stereotyped behavior in familiar environments. We hypothesized that expression of anxiogenic behavior in response to CRF will also be exhibited in a teleost fish. Rainbow trout were treated with intracerebroventricular (icv) injections of artificial cerebrospinal fluid (aCSF), 500 or 2000 ng ovine CRF, or not injected. Treatment with either dose of CRF elicited greater locomotion and pronounced head shaking behavior but did not influence water column position. Locomotor and head shaking behaviors may be analogous to the increased stereotypy evoked by icv CRF in rats and may reflect the expression of stress/anxiety behavior. Injection with either aCSF or CRF produced significant increases in plasma cortisol. The absence of behavioral changes in aCSF-injected fish suggests that the behavioral responses following CRF were not due to cortisol. Treatment with 2000 ng CRF significantly increased serotonin, 5-HIAA and dopamine concentrations in the subpallium and raphé and increased 5-HIAA in the preoptic hypothalamus (POA). Concurrent effects of CRF on central monoamines, locomotion and head shaking in trout suggest that anxiogenic properties of CRF are evolutionarily conserved. In addition, positive linear correlations between locomotion and serotonergic and dopaminergic function in the subpallium, POA and raphé nuclei suggest a locomotory function for these monoamines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.