ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
Diagnostic value of PET-measured heterogeneity in myocardial blood flows during cold pressor testing for the identification of coronary vasomotor dysfunction.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Optimal medical care and coronary flow capacity-guided myocardial revascularization vs usual care for chronic coronary artery disease: the CENTURY trial.European heart journal · 2025Trial
- Prevalence of impaired flow-mediated epicardial vasodilation among different types of coronary flow regulation.The international journal of cardiovascular imaging · 2026Article
- Quantitative flow ratio derived pullback pressure gradient and CZT-SPECT measured longitudinal flow gradient for hemodynamically significant coronary artery disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Coronary Microvascular Dysfunction: PET, CMR and CT Assessment.Journal of clinical medicine · 2021Review
- Clinical Quantification of Myocardial Blood Flow Using PET: Joint Position Paper of the SNMMI Cardiovascular Council and the ASNC.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- PET-measured longitudinal flow gradient correlates with invasive fractional flow reserve in CAD patients.European heart journal. Cardiovascular Imaging · 2017Article
- Coronary microvascular dysfunction in women with nonobstructive ischemic heart disease as assessed by positron emission tomography.Cardiovascular diagnosis and therapy · 2017Review
- Positron Emission Tomography-Determined Hyperemic Flow, Myocardial Flow Reserve, and Flow Gradient-Quo Vadis?Frontiers in cardiovascular medicine · 2017Review
- Myocardial blood flow: Putting it into clinical perspective.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Article
- Longitudinal myocardial blood flow gradient and CAD detection.Current cardiology reports · 2015Review
- Absolute quantitation of myocardial blood flow in human subjects with or without myocardial ischemia using dynamic flurpiridaz F 18 PET.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2014Article
- Safety and feasibility of regadenoson use for suboptimal heart rate response during symptom-limited standard Bruce exercise stress test.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2012Article
- Partial volume correction incorporating Rb-82 positron range for quantitative myocardial perfusion PET based on systolic-diastolic activity ratios and phantom measurements.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2011Article
- Structural epicardial disease and microvascular function are determinants of an abnormal longitudinal myocardial blood flow difference in cardiovascular risk individuals as determined with PET/CT.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2010Article
- Structural alterations of the coronary arterial wall are associated with myocardial flow heterogeneity in type 2 diabetes mellitus.European journal of nuclear medicine and molecular imaging · 2009Article
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Authors and funding
10 authors.
Funding
Abstract
backgroundWe aimed to evaluate the diagnostic value of a positron emission tomography (PET)-measured heterogeneity in longitudinal myocardial blood flow (MBF) during cold pressor testing (CPT) and global MBF response to CPT from rest (DeltaMBF) for identification of coronary vasomotor dysfunction. METHODS AND
resultsIn 35 patients CPT-induced alterations in epicardial luminal area were determined with quantitative angiography as the reference. MBF was assessed over the whole left ventricle as global MBF and regionally in the mid and mid-distal myocardium as MBF difference or MBF heterogeneity with nitrogen-13 ammonia and PET. The sensitivity and specificity of a longitudinal MBF difference during CPT in the identification of epicardial vasomotor dysfunction were significantly higher than the global DeltaMBF to CPT (88% vs 79% and 82% vs 64%, respectively; P < .05). Combining both parameters resulted in an optimal sensitivity of 100% at the expense of an intermediate specificity of 73%. The diagnostic accuracy was higher for the combined analysis than that for the MBF difference alone and global DeltaMBF alone (91% vs 86% and 74%, respectively; P < .05).
conclusionsThe combined evaluation of a CPT-induced heterogeneity in longitudinal MBF and the change in global MBF from rest may emerge as a new promising analytic approach to further optimize the identification and characterization of coronary vasomotor dysfunction.
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