Evidence map›Paper›PMID 17825602›Full record

ReviewOral oncology2008

Critical evaluation of diagnostic aids for the detection of oral cancer.

Mark W Lingen, John R Kalmar, Theodore Karrison, Paul M Speight

2 registry-linked trialsOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Oral oncology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 254 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
254citing papers in PubMed, 13 pooled it
17.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01361100 naunknown statusnot on this mapstarted 2010, after this paper: background citation

Evaluation of the Oncoral® Test in Epidermoid Carcinomas of the Upper Aerodigestive Tract

TypeinterventionalSponsorCentre Leon BerardRan2010 to 2015Enrolled485ConditionsCarcinomaArmsOncoral® test
NCT04896528 phase2unknown statusnot on this mapstarted 2021, after this paper: background citation

Efficacy and Safety of Avatrombopag in Cancer Patients With Thrombocytopenia Induced by Targeted Therapy and Immunotherapy Combination Treatment

TypeinterventionalSponsorPeking Union Medical College HospitalRan2021 to 2021Enrolled30ConditionsThrombocytopenia, AvatrombopagArmsAvatrombopag
3 · Its place in the literature

Who cites it

254 citing papers in PubMed, 13 syntheses or guidelines pooled it, 701 citations in OpenAlex.

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  13. Screening programmes for the early detection and prevention of oral cancer.The Cochrane database of systematic reviews · 2013
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194 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Mark W LingenDepartment of Pathology, The University of Chicago, Pritzker School of Medicine, 5841 S. Maryland Avenue, Chicago, IL 60637, USA. mark.lingen@uchospitals.edu
John R Kalmar
Theodore Karrison
Paul M Speight
University of Chicago · USThe Ohio State University · USUniversity of Sheffield · GB

Funding

Molecular Profiling of Premalignant Oral LesionsR01DE015830 · NIDCR · UNIVERSITY OF CHICAGO · PI LINGEN, MARK W. · 2005 to 2008
$1.3M
NIDCR NIH HHS DE015830NIDCR NIH HHS R01 DE015830
6 · The paper itself

Abstract

Historically, the screening of patients for signs of oral cancer and precancerous lesions has relied upon the conventional oral examination. A variety of commercial diagnostic aids and adjunctive techniques are available to potentially assist in the screening of healthy patients for evidence of otherwise occult cancerous change or to assess the biologic potential of clinically abnormal mucosal lesions. This manuscript systematically and critically examines the literature associated with current oral cancer screening and case-finding aids or adjuncts such as toluidine blue, brush cytology, tissue reflectance and autofluorescence. The characteristics of an ideal screening test are outlined and the authors pose several questions for clinicians and scientists to consider in the evaluation of current and future studies of oral cancer detection and diagnosis. Although the increased public awareness of oral cancer made possible by the marketing of recently-introduced screening adjuncts is commendable, the tantalizing implication that such technologies may improve detection of oral cancers and precancers beyond conventional oral examination alone has yet to be rigorously confirmed.

Indexed as

Coloring AgentsCytological TechniquesFluorescenceHumansMass ScreeningMouth NeoplasmsPrecancerous ConditionsSpectrophotometryTolonium ChlorideColoring AgentsTolonium Chloride

Identifiers

PMID17825602
PMCPMC2424250
OpenAlexW2123823520

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.