ArticleGenes to cells : devoted to molecular & cellular mechanisms2007
Condensin function at centromere chromatin facilitates proper kinetochore tension and ensures correct mitotic segregation of sister chromatids.
Article in Genes to cells : devoted to molecular & cellular mechanisms, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 51 citations in OpenAlex.
- Mammalian metaphase kinetochores are elastic and require condensin for robust structure and function.bioRxiv : the preprint server for biology · 2025Article
- Review
- Mitotic chromosome condensation requires phosphorylation of the centromeric protein KNL-2 in C. elegans.Journal of cell science · 2021Article
- The selfish yeast plasmid utilizes the condensin complex and condensed chromatin for faithful partitioning.PLoS genetics · 2021Article
- A Condensed View of the Chromosome Passenger Complex.Trends in cell biology · 2020Review
- Condensin Depletion Causes Genome Decompaction Without Altering the Level of Global Gene Expression inGenetics · 2018Article
- Subunits of human condensins are potential therapeutic targets for cancers.Cell division · 2018Article
- Transcription of a B chromosome CAP-G pseudogene does not influence normal Condensin Complex genes in a grasshopper.Scientific reports · 2017Article
- HJURP interaction with the condensin II complex during G1 promotes CENP-A deposition.Molecular biology of the cell · 2017Article
- Condensin Relocalization from Centromeres to Chromosome Arms Promotes Top2 Recruitment during Anaphase.Cell reports · 2015Article
- Shugoshins: tension-sensitive pericentromeric adaptors safeguarding chromosome segregation.Molecular and cellular biology · 2015Review
- From equator to pole: splitting chromosomes in mitosis and meiosis.Genes & development · 2015Review
- Defective histone supply causes condensin-dependent chromatin alterations, SAC activation and chromosome decatenation impairment.Nucleic acids research · 2014Article
- Dyskerin, tRNA genes, and condensin tether pericentric chromatin to the spindle axis in mitosis.The Journal of cell biology · 2014Article
- The condensin complexes play distinct roles to ensure normal chromosome morphogenesis during meiotic division in Arabidopsis.The Plant journal : for cell and molecular biology · 2014Article
- Sgo1 regulates both condensin and Ipl1/Aurora B to promote chromosome biorientation.PLoS genetics · 2014Article
- Analysis and Modeling of Chromosome Congression During Mitosis in the Chemotherapy Drug Cisplatin.Cellular and molecular bioengineering · 2013Article
- Individual pericentromeres display coordinated motion and stretching in the yeast spindle.The Journal of cell biology · 2013Article
- Monopolin recruits condensin to organize centromere DNA and repetitive DNA sequences.Molecular biology of the cell · 2013Article
- Pericentric chromatin loops function as a nonlinear spring in mitotic force balance.The Journal of cell biology · 2013Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The condensin complex is essential for sister chromatid segregation in eukaryotic mitosis. Nevertheless, in budding yeast, condensin mutations result in massive mis-segregation of chromosomes containing the nucleolar organizer, while other chromosomes, which also contain condensin binding sites, remain genetically stable. To investigate this phenomenon we analyzed the mechanism of the cell-cycle arrest elicited by condensin mutations. Under restrictive conditions, the majority of condensin-deficient cells arrest in metaphase. This metaphase arrest is mediated by the spindle checkpoint, particularly by the spindle-kinetochore tension-controlling pathway. Inactivation of the spindle checkpoint in condensin mutants resulted in frequent chromosome non-disjunction, eliminating the bias in chromosome mis-segregation towards rDNA-containing chromosomes. The spindle tension defect in condensin-impaired cells is likely mediated by structural defects in centromere chromatin reflected by the partial loss of the centromere histone Cse4p. These findings show that, in addition to its essential role in rDNA segregation, condensin mediates segregation of the whole genome by maintaining the centromere structure in Saccharomyces cerevisiae.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.