ArticleJournal of molecular histology2008
Immunohistochemical localization of apelin in human normal breast and breast carcinoma.
Article in Journal of molecular histology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- International Union of Basic and Clinical Pharmacology. CXXI. Apelin receptor pharmacology in the human cardiovascular system and emerging clinical applications.Pharmacological reviews · 2026Review
- Significance of Serum Apelin Levels as a Biomarker for Gastric Cancer Diagnosis.Asian Pacific journal of cancer prevention : APJCP · 2023Article
- Review
- The wonder exerkines-novel insights: a critical state-of-the-art review.Molecular and cellular biochemistry · 2022Review
- High APLN Expression Predicts Poor Prognosis for Glioma Patients.Oxidative medicine and cellular longevity · 2022Article
- Human Milk Metabolic Hormones: Analytical Methods and Current Understanding.International journal of molecular sciences · 2021Review
- Evaluation of Apelin/APJ system expression in hepatocellular carcinoma as a function of clinical severity.Clinical and experimental medicine · 2021Article
- Breast milk apelin level increases with maternal obesity and high-fat feeding during lactation.International journal of obesity (2005) · 2021Article
- The effects of apoptosis and apelin on lymph node metastasis in invasive breast carcinomas.Clinical and experimental medicine · 2020Article
- The Adipokines in Cancer Cachexia.International journal of molecular sciences · 2020Review
- Unraveling the Genomic-Epigenomic Interaction Landscape in Triple Negative and Non-Triple Negative Breast Cancer.Cancers · 2020Article
- The Role of Adipokines in Breast Cancer: Current Evidence and Perspectives.Current obesity reports · 2019Review
- Apelin inhibition prevents resistance and metastasis associated with anti-angiogenic therapy.EMBO molecular medicine · 2019Article
- MicroRNA-195 suppresses the progression of lung adenocarcinoma by directly targeting apelin.Thoracic cancer · 2019Article
- A Preliminary Study of Serum Apelin Levels in Patients with Head and Neck Cancer.The Eurasian journal of medicine · 2019Article
- Apelin System in Mammary Gland of Sheep Reared in Semi-Natural Pastures of the Central Apennines.Animals : an open access journal from MDPI · 2018Article
- The Role of Apelin in Cardiovascular Diseases, Obesity and Cancer.Frontiers in physiology · 2018Review
- High apelin levels could be used as a diagnostic marker in multiple myeloma: A comparative study.Cancer biomarkers : section A of Disease markers · 2016Article
- Adipokines in breast milk: an update.Journal of clinical research in pediatric endocrinology · 2014Review
- Apelin promotes lymphangiogenesis and lymph node metastasis.Oncotarget · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The peptide apelin is a high-affinity ligand for the G-protein coupled receptor APJ. Apelin/APJ signaling plays important roles in blood pressure regulation, body fluid homeostasis, and cardiovascular development. More recently, it has been recognized that apelin/APJ signaling may also be involved in tumor angiogenesis. Studies in experimental animals have shown that apelin is abundantly secreted in the milk, and the mammary gland contains high level of pre-proapelin mRNAs and apelin protein. High level of apelin mRNA is expressed in cultured human breast carcinoma cell line (Hs 578T). However, the status of apelin expression and localization in human breast carcinoma has not been studied. In the present study immunohistochemistry was performed to investigate the expression and localization of apelin in normal human breast tissue and breast carcinoma. Cytoplasmic apelin immunoreactivity was detected in the ductal and lobular epithelial cells and vascular endothelial cells of the normal breast tissue. The myoepithelial cells were negative. The malignant tumor cells of invasive ductal or lobular carcinoma also expressed similar level of immunoreactive apelin. The fuctional significance of apelin expression in normal nonlactating breast and breast carcinoma warrants further investigation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.