ArticleVirchows Archiv : an international journal of pathology2007
Interaction between dendritic cells and nerve fibres in lymphoid organs after oral scrapie exposure.
Article in Virchows Archiv : an international journal of pathology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed, 16 citations in OpenAlex.
- Cholinergic Activation Enhances Resistance to OralFrontiers in immunology · 2018Article
- The Neuromodulation of the Intestinal Immune System and Its Relevance in Inflammatory Bowel Disease.Frontiers in immunology · 2015Review
- Orally administered prion protein is incorporated by m cells and spreads into lymphoid tissues with macrophages in prion protein knockout mice.The American journal of pathology · 2011Article
- Spreading of prions from the immune to the peripheral nervous system: a potential implication of dendritic cells.Histochemistry and cell biology · 2010Article
- Neuroinvasion in prion diseases: the roles of ascending neural infection and blood dissemination.Interdisciplinary perspectives on infectious diseases · 2010Article
- Review
- Neural networks in intestinal immunoregulation.OrganogenesisReview
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In transmissible spongiform encephalopathies (TSEs), the infectious agent, called PrPsc, an abnormal isoform of the cellular prion protein, accumulates and replicates in lymphoid organs before affecting the nervous system. To clarify the cellular requirements for the neuroinvasion of the scrapie agent from the lymphoid organs to the central nervous system, we have studied, by confocal microscopy, the innervations within Peyer's patches, mesenteric lymph nodes and the spleen of mice in physiological conditions and after oral exposure to prion. Contacts between nerve fibres and PrPsc-associated cells, dendritic cells (DCs) and follicular dendritic cells (FDCs), were evaluated in preclinical prion-infected mice. Using a double immunolabelling strategy, we demonstrated the lack of innervation of PrPsc-accumulating cells (FDCs). Contacts between nerve fibers and PrPsc-propagating cells (DCs) were detected in T-cell zones and cell-trafficking areas. This supports, for the first time, the possible implication of dendritic cells in the prion neuroinvasion process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.