ArticlePediatric radiology2007
The use of short-echo-time 1H MRS for childhood cerebellar tumours prior to histopathological diagnosis.
Article in Pediatric radiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 41 citations in OpenAlex.
- Added value of magnetic resonance spectroscopy for diagnosing childhood cerebellar tumours.NMR in biomedicine · 2022Article
- Article
- Magnetic resonance spectroscopy in posterior fossa tumours: the tumour spectroscopic signature may improve discrimination in adults among haemangioblastoma, ependymal tumours, medulloblastoma, and metastasis.European radiology · 2019Article
- Prospective multicentre evaluation and refinement of an analysis tool for magnetic resonance spectroscopy of childhood cerebellar tumours.Pediatric radiology · 2018Article
- Diffusion MRI improves the accuracy of preoperative diagnosis of common pediatric cerebellar tumors among reviewers with different experience levels.AJNR. American journal of neuroradiology · 2013Article
- Juvenile idiopathic arthritis: clinically relevant imaging in diagnosis and monitoring.Pediatric radiology · 2008Review
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundProton magnetic resonance spectroscopy (MRS) measures concentrations of metabolites in vivo and provides a powerful method for identifying tumours. MRS has not entered routine clinical use partly due to the difficulty of analysing the spectra.
objectiveTo create a straightforward method for interpreting short-echo-time MRS of childhood cerebellar tumours. MATERIALS AND
methodsSingle-voxel MRS (1.5-T Siemens Symphony NUM4, TR/TE 1,500/30 ms) was performed at presentation in 30 children with cerebellar tumours. The MRS results were analysed for comparison with histological diagnosis. Peak heights for N-acetyl aspartate (NAA), creatine (Cr), choline (Cho) and myo-inositol (mIns) were determined and receiver operator characteristic curves used to select ratios that best discriminated between the tumour types. The method was implemented by a group of clinicians and scientists, blinded to the results.
resultsA total of 27 MRS studies met the quality control criteria. NAA/Cr >4.0 distinguished all but one of the astrocytomas from the other tumours. A combination of Cr/Cho <0.75 and mIns/NAA <2.1 separated all the medulloblastomas from the ependymomas.
conclusionPeak height ratios from short-echo-time MRS can accurately predict the histopathology of childhood cerebellar tumours.
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