ArticleThe review of diabetic studies : RDS2007
The cross-regulatory relationship between human dendritic and regulatory T cells and its role in type 1 diabetes mellitus.
Article in The review of diabetic studies : RDS, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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Who cites it
3 citing papers in PubMed.
- A role for anti-CD45RB monoclonal antibody treatment upon dendritic cells.Immunologic research · 2012Article
- From Toll-like receptors to the toll house of type 1 diabetes mellitus.Journal of molecular medicine (Berlin, Germany) · 2010Article
- Functional alterations of proinflammatory monocytes by T regulatory cells: implications for the prevention and reversal of type 1 diabetes.The review of diabetic studies : RDS · 2010Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dendritic cells (DCs) and T regulatory (Treg) cells play a crucial role in maintaining the tolerance needed to prevent the onset of autoimmunity that leads to the development of type 1 diabetes mellitus (T1DM). Various experimental studies have shown that human DC subsets are involved in the induction of anergy in T cells and in the differentiation of conventional CD4(+) and CD8(+) lymphocytes into the respective subtypes of Treg cells. Treg cells, in turn, have been shown to modulate the function of DCs to exhibit tolerogenic properties. To evaluate whether T1DM development is related to abnormalities in DCs and Treg cells, many attempts have been made to characterize these cell types in diabetic individuals and in subjects at risk of developing the disease. This review aims to supply an update on the progress made in these aspects of T1DM research.
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Registered trials
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