ArticleToxicological sciences : an official journal of the Society of Toxicology2008
Identification of a transcriptional fingerprint of estrogen exposure in rainbow trout liver.
Article in Toxicological sciences : an official journal of the Society of Toxicology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 61 citations in OpenAlex.
- Stage-specific testicular protein levels of the oestrogen receptors (ERα and ERβ) and Cyp19 and association with oestrogenic contamination in the lambari Astyanax rivularis (Pisces: Characidae).Environmental science and pollution research international · 2018Article
- Molecular characterization and expression profile of the estrogen receptor α gene during different reproductive phases in Monopterus albus.Scientific reports · 2016Article
- Identification of conserved hepatic transcriptomic responses to 17β-estradiol using high-throughput sequencing in brown trout.Physiological genomics · 2015Article
- Cancer chemoprevention by dietary chlorophylls: a 12,000-animal dose-dose matrix biomarker and tumor study.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2012Article
- Promotion of hepatocarcinogenesis by perfluoroalkyl acids in rainbow trout.Toxicological sciences : an official journal of the Society of Toxicology · 2012Article
- The rainbow trout liver cancer model: response to environmental chemicals and studies on promotion and chemoprevention.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2012Review
- Applications for next-generation sequencing in fish ecotoxicogenomics.Frontiers in genetics · 2012Article
- Integration of next-generation sequencing based multi-omics approaches in toxicogenomics.Frontiers in genetics · 2012Article
- Estrogen-like activity of perfluoroalkyl acids in vivo and interaction with human and rainbow trout estrogen receptors in vitro.Toxicological sciences : an official journal of the Society of Toxicology · 2011Article
- The effects of estrogenic and androgenic endocrine disruptors on the immune system of fish: a review.Ecotoxicology (London, England) · 2011Review
- Methoxychlor affects multiple hormone signaling pathways in the largemouth bass (Micropterus salmoides) liver.Aquatic toxicology (Amsterdam, Netherlands) · 2011Article
- Proteomic profiling of liver from Atlantic salmon (Salmo salar) fed genetically modified soy compared to the near-isogenic non-GM line.Marine biotechnology (New York, N.Y.) · 2010Article
- Genomic profiling reveals an alternate mechanism for hepatic tumor promotion by perfluorooctanoic acid in rainbow trout.Environmental health perspectives · 2008Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The goal of this study was to identify a set of hepatic genes regulated by ligand-dependent activation of the estrogen receptor in juvenile rainbow trout (Oncorhynchus mykiss). A custom rainbow trout oligo DNA microarray, which contains probes targeting approximately 1450 genes relevant to carcinogenesis, toxicology, endocrinology, and stress physiology was utilized to identify transcriptional fingerprints of in vivo dietary exposure to 17 beta-estradiol (E2), tamoxifen (TAM), estradiol + tamoxifen (E2 + TAM), diethylstilbestrol (DES), dehydroepiandrosterone (DHEA), dihydrotestosterone (DHT), and cortisol (CORT). Estrogen exposure altered the expression of up to 49 genes involved in reproduction, immune response, cell growth, transcriptional regulation, protein synthesis and modification, drug metabolism, redox regulation, and signal transduction. E2, DES, and DHEA regulated 18 genes in common, mostly those associated with vitellogenesis, cell proliferation, and signal transduction. Interestingly, DHEA uniquely regulated several complement component genes of importance to immune response. While the effect of TAM on E2-induced changes in gene expression was mostly antagonistic, TAM alone increased expression of VTG1 and other genes associated with egg development and immune response. Few genes responded to CORT treatment, and DHT significantly altered expression of only one gene targeted by the OSUrbt array. Hierarchical cluster and principal components analyses revealed distinct patterns of gene expression corresponding to estrogens and non-estrogens, though unique patterns could also be detected for individual chemicals. A set of estrogen-responsive genes has been identified that can serve as a biomarker of environmental exposure to xenoestrogens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.